Hb and dyslipidaemia as predicting markers of serum alanine aminotransferase elevation in Chinese adolescents

Autor: Eddy Owaga, Wen-Harn Pan, Chyi Huey Bai, Jung Su Chang, Kuo Ching Chao, Tzu chieh Huang, Chun Chao Chang
Rok vydání: 2015
Předmět:
Blood Glucose
Male
medicine.medical_specialty
Adolescent
Cross-sectional study
Taiwan
Medicine (miscellaneous)
Gastroenterology
Body Mass Index
Elevated serum
03 medical and health sciences
Hemoglobins
0302 clinical medicine
Asian People
Risk Factors
Internal medicine
medicine
Humans
030212 general & internal medicine
Aspartate Aminotransferases
Alanine aminotransferase
Setting national
Triglycerides
Dyslipidemias
Metabolic Syndrome
Nutrition and Dietetics
biology
business.industry
Cholesterol
HDL
Public Health
Environmental and Occupational Health
Alanine Transaminase
Cholesterol
LDL
Nutrition Surveys
Research Papers
Endocrinology
Cross-Sectional Studies
Quartile
Alanine transaminase
Liver
Cardiovascular Diseases
biology.protein
030211 gastroenterology & hepatology
Female
Liver function
business
Body mass index
Biomarkers
Zdroj: Public Health Nutr
ISSN: 1475-2727
1368-9800
Popis: ObjectiveFe is an essential element for erythropoiesis and Hb synthesis. High Hb levels affect the blood’s viscosity and are associated with cardiovascular dysfunction. The aim of the present study was to examine relationships of Hb and cardiometabolic abnormalities with the risk of alanine aminotransferase (ALT) elevation in adolescents.DesignA population-based, cross-sectional study.SettingNational Nutrition and Health Survey in Taiwan (2010–2011, adolescents).SubjectsHealthy adolescents aged 13–18 years.ResultsIn total, 1941 adolescents (963 boys and 978 girls) were entered in the study. The mean age was 15·3 (sd0·1) years (boys, 15·3 (sd0·1) years; girls, 15·2 (sd0·1) years). ALT tertile cut-off points for boys were 11 and 16 U/l, and for girls were 9 and 12 U/l. Girls without dyslipidaemia and presenting in the highest quartile (Q1) of Hb (>13·6 g/dl) were 1·89 and 3·76 times more likely to have raised serum ALT (9 and >12 U/l, respectively) than the reference (lowest quartile of Hb (Q1), 12 U/l) than the reference (Q1 of Hb, 15·4 g/dl), who were 7·40 times more likely to have elevated serum ALT of >16 U/l than the reference (Q1 of Hb, ConclusionsOur findings suggest that an increased Hb level is a predictor of elevated serum ALT in adolescent girls with dyslipidaemia. Our study also highlights the importance of further research to establish cut-off points for Hb and its utility in diagnosing and preventing the onset of dyslipidaemia in adolescents.
Databáze: OpenAIRE
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