Decreased expression of LIF mRNA in patients withmyoma uteri
| Autor: | Turhan Aran, Neziha Yilmaz, Ozlem Kara, Mustafa Kara, Seda Sabah Ozcan |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Infertility medicine.medical_specialty Leukemia Inhibitory Factor Biochemistry 03 medical and health sciences 0302 clinical medicine Follicular phase Biomarkers Tumor medicine Humans In patient Molecular Biology Homeodomain Proteins Gynecology business.industry Last menstrual period Myoma Mean age Cell Biology Prognosis medicine.disease Polycystic ovary Homeobox A10 Proteins 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Uterine Neoplasms Female Surgical history business |
| Zdroj: | Journal of Cellular Biochemistry. 120:3423-3427 |
| ISSN: | 1097-4644 0730-2312 |
| Popis: | OBJECTIVE The aim of this study was to evaluate endometrial receptivity by measuring HOXA-10, HOXA-11, and LIF gene expressions in women with polycystic ovary syndrome. METHODS A total of 48 women were included in this clinical study. Thepatients were allocated to two groups: study group consisted of 28 patients with myoma uteri and control group consisted of 20 patients without myoma uteri. Endometrial sampling was performed during the proliferative phase. The biopsies obtained from the patients with myoma uteri were taken from the place where the fibroids were localized. HOXA-10, HOXA-11, and LIF expressions were measured in the endometrial sampling material. Demographic data of the patients such as age, obstetric and gynecologic history, medical conditions, medications, surgical history, last menstrual period were recorded. Also, the number, size, localization, and type of the myoma were registered. RESULTS The mean age of the patients was 42.07 and 38.17, respectively. HOXA-11 levels in the study and control groups were 0.004 ± 0.001 and 0.010 ± 0.001, respectively ( P |
| Databáze: | OpenAIRE |
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