Five Patients With Burning Mouth Syndrome in Whom an Antidepressant (Serotonin-Noradrenaline Reuptake Inhibitor) Was Not Effective, but Pregabalin Markedly Relieved Pain
| Autor: | Norio Ozaki, Tomoya Miyauchi, Masako Tachibana, Hiroyuki Kimura, Eri Umemura, Yuka Kobayashi, Munetaka Arao, Tatsuya Tokura, Keizo Yoshida, Mikiko Ito, Kenichi Kurita, Wataru Nagashima |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pregabalin Burning Mouth Syndrome chemistry.chemical_compound Milnacipran medicine Humans Duloxetine Pharmacology (medical) Amitriptyline Aged Pharmacology Analgesics business.industry Middle Aged Burning mouth syndrome Antidepressive Agents chemistry Anesthesia Neuropathic pain Antidepressant Female Neurology (clinical) Nortriptyline medicine.symptom business medicine.drug |
| Zdroj: | Clinical Neuropharmacology. 38:158-161 |
| ISSN: | 0362-5664 |
| Popis: | Burning mouth syndrome (BMS) causes idiopathic pain or a burning sensation in clinically normal oral mucosa. Burning mouth syndrome is a chronic disease with an unknown etiology. Burning mouth syndrome is also idiopathic, and a consensus regarding diagnosis/treatment has not been reached yet. Recent studies have supported the suggestion that BMS is a neuropathic pain disorder in which both the peripheral and central nervous systems are involved. Tricyclic antidepressants (nortriptyline and amitriptyline), serotonin-noradrenaline reuptake inhibitors (SNRIs) (duloxetine and milnacipran), and antiepileptic drugs, potential-dependent calcium channel α2δ subunit ligands (gabapentine and pregabalin), are currently recommended as the first-choice drugs for neuropathic pain. In this study, we report 5 patients with BMS in whom there was no response to SNRI (milnacipran or duloxetine), or administration was discontinued because of adverse reactions, but in whom pregabalin therapy markedly reduced or led to the disappearance of pain in a short period. Pregabalin, whose mechanism of action differs from that of SNRIs, may become a treatment option for BMS patients who are not responsive to or are resistant to SNRIs. |
| Databáze: | OpenAIRE |
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