Designer protein pseudo-capsids targeting intracellular bacteria
| Autor: | Camilla Dondi, Nilofar Faruqui, Stephanie Rey, Maxim G. Ryadnov, Alex Hoose |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.drug_class
Antibiotics Biomedical Engineering Microbial Sensitivity Tests 02 engineering and technology Microbiology 03 medical and health sciences Capsid Drug Resistance Multiple Bacterial medicine General Materials Science 030304 developmental biology 0303 health sciences Bacteria biology Host (biology) Chemistry Intracellular parasite 021001 nanoscience & nanotechnology Antimicrobial biology.organism_classification Anti-Bacterial Agents 0210 nano-technology Antimicrobial Cationic Peptides |
| Zdroj: | Biomaterials Science. 9:6807-6812 |
| ISSN: | 2047-4849 2047-4830 |
| Popis: | The emergence of multidrug-resistant bacteria stimulates the search for antimicrobial materials capable of addressing challenges conventional antibiotics fail to address. The ability to target intracellular bacteria remains one of the most fundamental tasks for contemporary antimicrobial treatments. Here we report engineered protein pseudo-capsids targeting bacteria internalised in macrophages. Using a combination of live-cell imaging and single-cell electron microscopy analysis we show that these materials effectively disrupt the bacteria without affecting the host cells. The study offers a disruptive antimicrobial strategy demonstrating potential for developing principally more challenging mechanisms for bacteria to overcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|