Indispensable amino acid deficiency and increased seizure susceptibility in rats
| Autor: | Jennifer A. Barrett, Kimberly D. Dixon, Dorothy W. Gietzen, A. C. Jones, B. G. Truong, D. S. Washburn |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Threonine medicine.medical_specialty Physiology Differential Threshold Stimulation Biology Bicuculline Drug Administration Schedule Injections Rats Sprague-Dawley Epilepsy Seizures Physiology (medical) Internal medicine Piriform cortex Convulsion Limbic System medicine Animals Histidine Amino Acids Isoleucine chemistry.chemical_classification Olfactory Pathways medicine.disease Rats Amino acid Endocrinology chemistry Pentylenetetrazole Disease Susceptibility medicine.symptom Injections Intraperitoneal medicine.drug |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 271:R18-R24 |
| ISSN: | 1522-1490 0363-6119 |
| Popis: | Repeated subthreshold stimulation of limbic brain areas increases seizure susceptibility in experimental models of epilepsy. In addition, acute dietary indispensable amino acid (IAA) deficiency activates the anterior piriform cortex (APC), a seizure-prone limbic brain area in the rat. Based on these two findings, we hypothesized that activation of the APC by chronic exposure to IAA-deficient diets might increase seizure susceptibility. Several nonessential amino acid neurotransmitters are important in seizures, but deficiencies of nontransmitter IAAs have not been well studied in seizure models. In four trials, we made injections of pentylenetetrazole intraperitoneally or of bicuculline into the APC in histidine-, isoleucine-, or threonine-deficient rats and controls. Increased susceptibility to seizures in the deficient animals was observed as increased severity of the seizures, decreased threshold for the dose of the chemostimulant and time to seizure, or a combination thereof. Pair-fed controls showed that this effect was not due to an energy deficit. This novel but robust finding suggests that IAA deficiency may increase vulnerability to seizures by repeated activation of the APC. |
| Databáze: | OpenAIRE |
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