Bariatric Surgery Impact on Reproductive Hormones, Semen Analysis, and Sperm DNA Fragmentation in Men with Severe Obesity: Prospective Study
| Autor: | Hamilton de Martin, Guilherme J. A. Wood, Davi V. Paluello, Marco Aurelio Santo, Marcello Cocuzza, William C. Nahas, Miguel Srougi, Bruno Camargo Tiseo |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Bariatric Surgery 030209 endocrinology & metabolism Semen DNA Fragmentation Semen analysis 03 medical and health sciences 0302 clinical medicine medicine Humans Prospective Studies Prospective cohort study Sperm motility Testosterone Infertility Male Nutrition and Dietetics medicine.diagnostic_test business.industry Luteinizing Hormone medicine.disease Obesity Sperm Spermatozoa Surgery Obesity Morbid Semen Analysis Sperm Motility 030211 gastroenterology & hepatology Follicle Stimulating Hormone business Hormone |
| Zdroj: | Obesity surgery. 30(12) |
| ISSN: | 1708-0428 |
| Popis: | Growing evidence in the literature suggests that obesity is capable of altering reproductive hormone levels and male fertility. Effects on classic semen parameters and sperm DNA fragmentation (SDF), however, have not been properly established. Additionally, the impact of bariatric surgery (BS) on those parameters is still controversial. In Phase 1, 42 patients with obesity and 32 fertile controls were submitted to reproductive hormone evaluation, semen analysis, and SDF testing. In Phase 2, patients with obesity were submitted to BS or clinical follow-up and were invited to 6-month revaluation. Phase 1: Men with obesity have higher levels of estradiol, LH, and FSH and lower levels of total testosterone (TT) when compared with eutrophic fertile men. Additionally, they present worse semen parameters, with reduction in ejaculated volume and sperm concentration, worse sperm motility and morphology, and higher SDF. Phase 2: 32 patients returned to revaluation. Eighteen were submitted to BS (group S) and 14 were not submitted to any specific therapeutic regimen (group NS). In group S, TT more than doubled after surgery (294.5 to 604 ng/dL, p |
| Databáze: | OpenAIRE |
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