Heightened orofacial, manual, and gait variability in Parkinson’s disease results from a general rhythmic impairment
| Autor: | Serge Pinto, Valentin Bégel, Valérie Driss, Frédéric Puyjarinet, Sonja A. Kotz, Marie-Charlotte Cuartero, Christian Geny, Simone Dalla Bella |
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| Přispěvatelé: | Euromov (EuroMov), Université de Montpellier (UM), Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Aix Marseille Université (AMU), Maastricht University [Maastricht], Laboratoire Parole et Langage (LPL), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), RS: FPN NPPP I, Section Neuropsychology, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
STIMULATION
medicine.medical_specialty Parkinson's disease Neural substrate media_common.quotation_subject [SDV]Life Sciences [q-bio] PATHOGENESIS Stimulus (physiology) Article 050105 experimental psychology lcsh:RC346-429 [SHS]Humanities and Social Sciences 03 medical and health sciences Cellular and Molecular Neuroscience [SCCO]Cognitive science 0302 clinical medicine Physical medicine and rehabilitation Rhythm Perception medicine 0501 psychology and cognitive sciences lcsh:Neurology. Diseases of the nervous system FESTINATION ComputingMilieux_MISCELLANEOUS media_common PERCEPTION MOVEMENTS 05 social sciences Diadochokinesia Neuropsychology SPEECH PERFORMANCE medicine.disease Neurology Neurological manifestations Finger tapping Neurology (clinical) Psychology MOTOR 030217 neurology & neurosurgery |
| Zdroj: | npj Parkinson's Disease npj Parkinson's Disease, Nature, 2019, 5 (1), ⟨10.1038/s41531-019-0092-6⟩ npj Parkinson's Disease, 5:19. Springer Nature npj Parkinson's Disease, Vol 5, Iss 1, Pp 1-7 (2019) npj Parkinson's Disease, 2019, 5 (1), ⟨10.1038/s41531-019-0092-6⟩ NPJ Parkinson's Disease |
| ISSN: | 2373-8057 |
| Popis: | Individuals with Parkinson’s disease (PD) experience rhythm disorders in a number of motor tasks, such as (i) oral diadochokinesis, (ii) finger tapping, and (iii) gait. These common motor deficits may be signs of “general dysrhythmia”, a central disorder spanning across effectors and tasks, and potentially sharing the same neural substrate. However, to date, little is known about the relationship between rhythm impairments across domains and effectors. To test this hypothesis, we assessed whether rhythmic disturbances in three different domains (i.e., orofacial, manual, and gait) can be related in PD. Moreover, we investigated whether rhythmic motor performance across these domains can be predicted by rhythm perception, a measure of central rhythmic processing not confounded with motor output. Twenty-two PD patients (mean age: 69.5 ± 5.44) participated in the study. They underwent neurological and neuropsychological assessments, and they performed three rhythmic motor tasks. For oral diadochokinesia, participants had to repeatedly produce a trisyllable pseudoword. For gait, they walked along a computerized walkway. For the manual task, patients had to repeatedly produce finger taps. The first two rhythmic motor tasks were unpaced, and the manual tapping task was performed both without a pacing stimulus and musically paced. Rhythm perception was also tested. We observed that rhythmic variability of motor performances (inter-syllable, inter-tap, and inter-stride time error) was related between the three functions. Moreover, rhythmic performance was predicted by rhythm perception abilities, as demonstrated with a logistic regression model. Hence, rhythm impairments in different motor domains are found to be related in PD and may be underpinned by a common impaired central rhythm mechanism, revealed by a deficit in rhythm perception. These results may provide a novel perspective on how interpret the effects of rhythm-based interventions in PD, within and across motor domains. |
| Databáze: | OpenAIRE |
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