Auditory and Language Development Assessment of Newborns Aged One to Four Years Exposed to Gestational Zika Virus Infection: A Case Series
| Autor: | Paula Silva de Carvalho Chagas, Jaqueline da Silva Frônio, Liora Gonik, Amanda Tupinambá da Fonseca Oliveira |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Hearing loss Language delay Health Toxicology and Mutagenesis Population Audiology Bayley Scales of Infant Development Language Development Article Zika virus 03 medical and health sciences 0302 clinical medicine Pregnancy Medicine Humans 030212 general & internal medicine Brainstem auditory evoked potential Prospective Studies education Child hearing loss child development education.field_of_study medicine.diagnostic_test biology business.industry Zika Virus Infection Hearing Tests Public Health Environmental and Occupational Health Infant Newborn Infant Zika Virus biology.organism_classification Child development Language development hearing Female medicine.symptom business 030217 neurology & neurosurgery children’s language |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 18, Iss 6562, p 6562 (2021) Volume 18 Issue 12 |
| ISSN: | 1660-4601 |
| Popis: | The known neurotropism of the Zika virus (ZikV) suggests that auditory organs and their neural pathways may be affected by prenatal Zika infections. Among the possible manifestations are audiological and language disorders, but so far, the data in the literature are inconclusive. Objective: To describe early and late hearing disorders in children with Congenital Zika Virus Infection (CZVI) and evaluate the language development of this population between 14 and 47 months of age and its possible correlation with the alterations found in auditory exams. Methods: Longitudinal, prospective, observational study of newborns born in Juiz de Fora and its macroregion with confirmed diagnosis of ZikV infection during pregnancy. Participants were examined from one to four years of age for hearing using the transient otoacoustic emissions (TOAE) test, immittance testing and brainstem auditory evoked potential (BAEP), and language using the Bayley Scales of Infant Development—Third Edition (Bayley III). Results: 15 participants were included eight (53.33%) presented alterations in at least one of the hearing tests, one had an early loss (6%) of sensorineural origin, and seven (46.67%) had a poor language performance. In the three (20%) participants whose audiological exams were altered, there was language impairment, and two (13.33%) participants had extensive malformations in the central nervous system (CNS), presented language delay, and hearing exams were within normality. Conclusion: Infants and preschoolers with CZVI may present early neurosensory loss and late hearing loss with fluctuating character. Even if there were no significant association between the audiological exams results and the Bayley III performance, in the present sample, language development was below expectations for the age in the participants who had alterations in the three audiological exams, when there is early hearing loss or extensive lesions to the CNS. The results reinforce the importance of audiological examinations, especially the BAEP morphological and auditory threshold, in monitoring cases of CZVI until at least three years of age. |
| Databáze: | OpenAIRE |
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