An Effective Salvage Regimen with Aclarubicin for Daunorubicin-Resistant Acute Non-Lymphocytic Leukemia in Children
| Autor: | Jun Okamura, Yoshiko Ikuno, Hideko Tasaka, Hiromichi Take, Fumio Yanai, Akinobu Matsuzaki, Sumio Miyazaki, Haruhiko Eguchi, Hiroko Inada, Keiko Nibu, Hideki Nakayama, Ryo Sakai, Hiroyuki Koga |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Anthracycline Daunorubicin medicine.medical_treatment Drug Resistance Gastroenterology Internal medicine medicine Humans Aclarubicin Child Salvage Therapy Chemotherapy business.industry Cumulative dose Hematology medicine.disease Surgery Leukemia Myeloid Acute Leukemia Oncology Bone marrow suppression Child Preschool Pediatrics Perinatology and Child Health Prednisolone Female business medicine.drug |
| Zdroj: | Pediatric Hematology and Oncology. 12:251-258 |
| ISSN: | 1521-0669 0888-0018 |
| Popis: | We evaluated the efficacy and toxicity of aclarubicin for acute non-lymphocytic leukemia (ANLL) refractory to daunorubicin in childhood. Twenty-four patients were treated with aclarubicin and prednisolone with or without 6-mercaptopurine and behenoyl-cytosine arabinoside daily for 5 to 14 days. Of 21 evaluable patients, 14 (67%) responded: 12 obtained complete remission and 2 partial remission. The median time to reach complete remission was 37 days (range, 16 to 60 days), and the median duration of complete remission was 5.5 months (range, 2 to 41 months). The cumulative dose of anthracycline administered before the study was not considered significant for the response. The only major complication was severe bone marrow suppression; infectious episodes occurred in 14 patients (58%) and three died of sepsis and/or bleeding. The observed non-hematologic toxicities included hematuria, an elevation of serum amylase, nausea/vomiting, and angitis. In addition, one patient showed abnormal cardiac function. Aclarubicin is therefore considered a highly active drug for remission reinduction of previously treated children suffering from ANLL with an acceptable toxicity. |
| Databáze: | OpenAIRE |
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