The Sleep Side of Aging and Alzheimer’s Disease
| Autor: | E. Testani, Alessandro Rossi, Simone Rossi, Sara M. Romanella, Rachel Paciorek, Emiliano Santarnecchi, D. Roe, Davide Cappon, Elisa Tatti |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aging
Tau protein tau Proteins Disease Article White matter 03 medical and health sciences 0302 clinical medicine Alzheimer Disease medicine Humans Dementia Aged Amyloid beta-Peptides Sensory stimulation therapy biology business.industry Cognition General Medicine medicine.disease medicine.anatomical_structure 030228 respiratory system Brain stimulation Synaptic plasticity Quality of Life biology.protein Sleep business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Sleep Med |
| ISSN: | 1389-9457 |
| DOI: | 10.1016/j.sleep.2020.05.029 |
| Popis: | As we age, sleep patterns undergo significant modifications in micro and macrostructure, worsening cognition and quality of life. These are associated with remarkable brain changes, like deterioration in synaptic plasticity, gray and white matter, and significant modifications in hormone levels. Sleep alterations are also a core component of mild cognitive impairment (MCI) and Alzheimer’s Disease (AD). AD night time is characterized by a gradual decrease in slow-wave activity and a substantial reduction of REM sleep. Sleep abnormalities can accelerate AD pathophysiology, promoting the accumulation of amyloid-β (Aβ) and phosphorylated tau. Thus, interventions that target sleep problems in elderly people and MCI patients have been suggested as a possible strategy to prevent or decelerate conversion to dementia. Although cognitive-behavioral therapy and pharmacological medications are still first-line treatments, despite being scarcely effective, new interventions have been proposed, such as auditory or light stimulation and Noninvasive Brain Stimulation (NiBS). Leveraging sleep research with NiBS possibilities is a new promising idea that may help to find AD biomarkers, address sleep symptomatology, and tackle Aβ deposition. The present review outlines the current state of the art of the relationship between sleep modifications in healthy aging and the neurobiological mechanisms underlying these age-related changes. Furthermore, we provide a critical analysis showing how sleep abnormalities influence the prognosis of AD pathology by intensifying Aβ and tau protein accumulation. We discuss potential therapeutic strategies to target sleep disruptions and conclude that there is an urgent need for testing these new therapeutic sleep interventions. |
| Databáze: | OpenAIRE |
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