Patients' prognosis of intrahepatic cholangiocarcinoma and combined hepatocellular‐cholangiocarcinoma after resection

Autor: Hisashi Nakayama, Masamichi Moriguchi, Peipei Song, Osamu Aramaki, Shintaro Yamazaki, Kenichi Teramoto, Masaru Aoki, Yutaka Midorikawa, Tokio Higaki, Tadatoshi Takayama
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
0301 basic medicine
Cancer Research
medicine.medical_specialty
Carcinoma
Hepatocellular
Gastroenterology
tumor number
lcsh:RC254-282
Resection
Vascular invasion
Cholangiocarcinoma
Young Adult
03 medical and health sciences
0302 clinical medicine
Statistical significance
Internal medicine
Humans
Medicine
Radiology
Nuclear Medicine and imaging
vascular invasion
Intrahepatic Cholangiocarcinoma
Original Research
Aged
Aged
80 and over
Tumor size
business.industry
ICC
tumor size
Liver Neoplasms
Significant difference
Clinical Cancer Research
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Survival Analysis
Confidence interval
Bile Ducts
Intrahepatic
030104 developmental biology
Bile Duct Neoplasms
Liver
Oncology
030220 oncology & carcinogenesis
Female
prognosis
business
cHCC‐CC
Zdroj: Cancer Medicine, Vol 8, Iss 13, Pp 5862-5871 (2019)
Cancer Medicine
ISSN: 2045-7634
Popis: Combined hepatocellular‐cholangiocarcinoma (cHCC‐CC) and intrahepatic cholangiocarcinoma (ICC) are classified into one category, but comparison of prognosis of the two carcinomas remains controversial. The aim of the current study was to investigate surgical outcomes for patients with ICC or cHCC‐CC who underwent resection in order to elucidate whether the classification of ICC and cHCC‐CC is justified. Subjects were 61 patients with ICC and 29 patients with cHCC‐CC who underwent liver resection from 2001 to 2017. Clinic‐pathological data from the two groups were compared. Tumor number and vascular invasion were independent risk factors for recurrence‐free survival (RFS) in both groups (P 5 cm vs ≤5 cm, 0.5 years vs 4.0 years, P = .003). For patients with cHCC‐CC, tumor cut‐off size of 2 cm showed statistical significance in median RFS (>2 cm vs ≤2 cm, 0.6 years vs 2.6 years, P = .038). The median RFS of patients with cHCC‐CC was 0.9 years (95% confidence interval: 0.3‐1.6), which was poorer than that of patients with ICC (1.3 years, 0.5‐2.1) (P = .028); the rate of RFS at 5 years was 0% and 37.7% respectively. Our study supports the concept of classifying ICC and cHCC‐CC into different categories because of a significant difference in RFS between the two.
Our study supports the concept of classifying ICC and cHCC‐CC into different categories because of a significant difference in RFS between the two.
Databáze: OpenAIRE
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