Clinical features and predictors for patients with severe SARS-CoV-2 pneumonia at the start of the pandemic: a retrospective multicenter cohort study
| Autor: | Guoqing Qian, Chuanbing Zhu, Yiting Li, Li He, Qingwen Jiang, Jinguo Chu, Weina Huang, Chao Cao, Lili Yu, Meiping Chen, Xiaomin Chen, Shiyu Wu, Jingping Ma |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty China Infectious and parasitic diseases RC109-216 030204 cardiovascular system & hematology Logistic regression 03 medical and health sciences 0302 clinical medicine Adrenal Cortex Hormones Internal medicine medicine Humans Corticosteroids 030212 general & internal medicine Lymphocyte Count Risk factor Prospective cohort study Pandemics Aged Retrospective Studies business.industry SARS-CoV-2 COVID-19 Retrospective cohort study Odds ratio Pneumonia Middle Aged medicine.disease Prognosis Virus Shedding Clinical trial Infectious Diseases Lymphocyte counts Risk factors Sample Size Female business Cohort study Research Article |
| Zdroj: | BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-7 (2021) BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| Popis: | Background This study was performed to investigate clinical features of patients with severe SARS-CoV-2 pneumonia and identify risk factors for converting to severe cases in those who had mild to moderate diseases at the start of the pandemic in China. Methods In this retrospective, multicenter cohort study, patients with mild to moderate SARS-CoV-2 pneumonia were included. Demographic data, symptoms, laboratory values, and clinical outcomes were collected. Data were compared between non-severe and severe patients. Results 58 patients were included in the final analysis. Compared with non-severe cases, severe patients with SARS-CoV-2 pneumonia had a longer: time to clinical recovery (12·9 ± 4·4 vs 8·3 ± 4·7; P = 0·0011), duration of viral shedding (15·7 ± 6·7 vs 11·8 ± 5·0; P = 0·0183), and hospital stay (20·7 ± 1·2 vs 14·4 ± 4·3; P = 0·0211). Multivariate logistic regression indicated that lymphocyte count was significantly associated with the rate of converting to severe cases (odds ratio 1·28, 95%CI 1·06–1·54, per 0·1 × 109/L reduced; P = 0·007), while using of low-to-moderate doses of systematic corticosteroids was associated with reduced likelihood of converting to a severe case (odds ratio 0·14, 95%CI 0·02–0·80; P = 0·0275). Conclusions The low peripheral blood lymphocyte count was an independent risk factor for SARS-CoV-2 pneumonia patients converting to severe cases. However, this study was carried out right after the start of the pandemic with small sample size. Further prospective studies are warranted to confirm these findings. Trial registration Chinese Clinical Trial Registry, ChiCTR2000029839. Registered 15 February 2020 - Retrospectively registered. |
| Databáze: | OpenAIRE |
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