Non-peptide angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitor: effect on a renin-induced deficit of a passive avoidance response in rats
| Autor: | Pieter B.M.W.M. Timmermans, Kimi F. DeNoble, Karen R. Spencer, Pancras C. Wong, Andrew T. Chiu, Victor J. DeNoble |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Captopril Time Factors Pyridines Tetrazoles Angiotensin II receptor antagonist Cerebral Ventricles Angiotensin Receptor Antagonists Reference Values Internal medicine Renin–angiotensin system Renin medicine Avoidance Learning Animals Receptor Molecular Biology Injections Intraventricular Receptors Angiotensin biology Chemistry General Neuroscience Angiotensin II Biphenyl Compounds Imidazoles Angiotensin-converting enzyme Rats Inbred Strains Rats Endocrinology ACE inhibitor biology.protein Neurology (clinical) Developmental Biology medicine.drug |
| Zdroj: | Brain research. 561(2) |
| ISSN: | 0006-8993 |
| Popis: | Non-peptide receptor ligands with differential affinity for the angiotensin II-1 (AII-1) receptor (EXP3312, EXP3880) or the AII-2 receptor (PD123177) and an angiotensin converting enzyme (ACE) inhibitor captopril were evaluated for the ability to protect against a renin-induced performance deficit in a passive avoidance (PA) task in rats. The ability to retain a PA response was shown to decrease as the dose of intracerebroventricularly (i.c.v.) administered renin increased with maximal retention deficits occurring at 1.0 micrograms/5 microliters i.c.v. EXP3312 (1-100 micrograms/5 microliters i.c.v.) and EXP3880 (1-100 micrograms/5 microliters i.c.v.) produced dose-dependent increases in retention latencies when co-administered with renin. The peak effect dose (PED) for EXP3312 and EXP3880 was 3 and 30 micrograms i.c.v., respectively. In contrast, PD123177 was not effective in preventing the renin-induced decrease in retention across a broad range of doses (0.1-100 micrograms/5 microliters i.c.v.). Captopril (1-100 micrograms/5 microliters i.c.v.) also prevented the renin-induced performance deficit with a PED of 30 micrograms/5 microliters i.c.v. These results suggest that renin given i.c.v. produces a deficit in performance of a PA response in rats and that this effect can be attenuated by an ACE inhibitor, AII-1 receptor ligands, but not AII-2 receptor blocker. |
| Databáze: | OpenAIRE |
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