Challenges in the Diagnosis and Management of Recurrent and Severe Clostridioides difficile Infection in Children

Autor:	Jonathan D. Crews, Matthew M Sattler
Rok vydání:	2021
Předmět:	medicine.medical_specialty genetic structures medicine.drug_class Fulminant Antibiotics Severe disease macromolecular substances Therapeutic approach Clostridioides Recurrence medicine Humans Child Intensive care medicine Clostridioides difficile business.industry Treatment options General Medicine Clostridium difficile Diarrhea Infectious Diseases Pediatrics Perinatology and Child Health Clostridium Infections medicine.symptom business
Zdroj:	Journal of the Pediatric Infectious Diseases Society. 10:S27-S33
ISSN:	2048-7207
DOI:	10.1093/jpids/piab079
Popis:	Children with Clostridioides difficile infection (CDI) can experience recurrent or severe disease. Recurrent CDI occurs in 20%-30% of children with an initial CDI episode. A careful clinical evaluation is important to distinguish recurrent CDI from other disorders that cause recurring gastrointestinal symptoms. Multiple treatment options exist for recurrent CDI, but the optimal therapeutic approach remains undefined. Severe or fulminant CDI can result in poor outcomes and significant morbidity in children. Since there is not a validated definition for severe CDI in children, physicians must use their clinical judgment to identify patients with severe CDI to institute appropriate therapy. In this review, we describe the diagnostic and management challenges in caring for children with recurrent and severe CDI.
Databáze:	OpenAIRE
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