Potassium Loss from Human Erythrocytes Exposed to Amphotericin B
| Autor: | William T. Butler, Ernest Cotlove, David W. Alling |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Cell Membrane Permeability
Erythrocytes Cell membrane permeability Potassium Sodium Kinetics chemistry.chemical_element General Biochemistry Genetics and Molecular Biology Cell membrane Amphotericin B medicine Humans Ions Pharmacology Research Sodium Dietary medicine.disease Hemolysis medicine.anatomical_structure chemistry Biophysics Human erythrocytes medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 118:297-300 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-118-29825 |
| Popis: | SummaryWhen fresh human erythrocytes are suspended in buffered solution containing amphotericin B, potassium loss begins within 3 minutes and continues for some time before appreciable hemolysis occurs. The kinetics of the potassium loss indicate that amphotericin B markedly increases cell membrane permeability. The concentration difference of potassium ion across the cell membrane decays at a rate which depends on the dose of amphotericin B. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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