Increased Serum and mRNA Levels of RANTES Associated with Elevated Levels of Activated CD8+CD38+ T Cells in HIV-1-Infected Individuals
| Autor: | Jens Braner, Schlomo Staszewski, Peter Müller, Martin Engelstädter, Reinhard Kurth, Hans-Wilhelm Doerr, Veronica Miller, Klaus Cichutek, Albrecht Werner |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
medicine.medical_specialty Chemokine Anti-HIV Agents T-Lymphocytes HIV Infections CD8-Positive T-Lymphocytes CD38 Lymphocyte Activation NAD+ Nucleosidase Antigens CD Virology Internal medicine medicine Humans Lymphocyte Count RNA Messenger ADP-ribosyl Cyclase Chemokine CCL4 Chemokine CCL5 Macrophage inflammatory protein Interleukin-16 Membrane Glycoproteins biology business.industry Macrophage Inflammatory Proteins Viral Load NAD+ nucleosidase ADP-ribosyl Cyclase 1 Antigens Differentiation Membrane glycoproteins Infectious Diseases Endocrinology Immunology Leukocytes Mononuclear biology.protein Interleukin 16 business Viral load CD8 |
| Zdroj: | Intervirology. 40:263-270 |
| ISSN: | 1423-0100 0300-5526 |
| Popis: | The serum levels of the beta-chemokine RANTES and, albeit less, MIP-1 beta were found to be increased in 37 HIV-1 infected compared to seronegative individuals. In contrast the serum levels of IL-16 were only sporadically elevated in seropositives as well as in seronegatives. Concomitantly, the RANTES gene expression increased about tenfold in seropositives, whereas the MIP-1 beta and IL-16 mRNA levels were not elevated. No correlation between the increase of the MIP-1 beta and RANTES serum concentrations and the plasma virus load, the number of the peripheral CD4+ T cells or the therapy status of the patients was found. However, the increased proportion of activated CD8+CD38+ T cells in the peripheral blood of all seropositives paralleled the increased RANTES serum levels detected indicating that immune activation in HIV-1-infected individuals may contribute to increased RANTES serum levels. |
| Databáze: | OpenAIRE |
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