Restricted IgG-Kappa and Free Alpha-Heavy-Chain Bands in an Asymptomatic 62-Year-Old Man
| Autor: | Lawrence M. Silverman, Jerry A. Katzmann, David E. Bruns, David L. Murray, Min Yu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Immunofixation
Male medicine.medical_specialty Clinical Biochemistry Urine 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences Immunoglobulin kappa-Chains 0302 clinical medicine Internal medicine medicine Humans biology medicine.diagnostic_test Transferrin saturation Chemistry Biochemistry (medical) Albumin Middle Aged Blood Protein Electrophoresis Thrombocytopenia 030220 oncology & carcinogenesis Serum protein electrophoresis Pseudothrombocytopenia Immunoglobulin G biology.protein Hemoglobin Densitometry Immunoglobulin Heavy Chains |
| Zdroj: | Clinical chemistry. 64(2) |
| ISSN: | 1530-8561 |
| Popis: | A 62-year-old Virginia man in good health was found on routine testing to have a decreased platelet count of 124k/μL (reference interval: 150–450k/μL). There was no evidence of bruising or bleeding, and there was no family history of thrombocytopenia. His weight was stable, and he had no complaints of pain and no gastrointestinal, musculoskeletal, or hematological symptoms. He denied fatigue, fevers, chills, and night sweats. Past medical history included hypothyroidism and chronic obstructive pulmonary disease. Physical examination was unremarkable. Other laboratory test results included hemoglobin of 13.8 g/dL (reference interval: 14.0–18.0 g/dL) and mean red-cell volume of 98.1 fL (reference interval: 83.0–95.0 fL). Plasma potassium was 4.1 mmol/L (reference interval: 3.5–4.5 mmol/L), calcium 8.8 mg/dL (reference interval: 8.8–10.5 mg/dL), albumin 4.23 g/dL (reference interval: 3.4–5.0 g/dL), and alkaline phosphatase 61 U/L (reference interval: 40–150 U/L). Review of a peripheral blood smear found no obvious evidence of pseudothrombocytopenia. Serum ferritin was 53 ng/mL (reference interval: 20–275 ng/mL) and iron saturation was 18% (reference interval: 16%–48%). Serum protein electrophoresis (Fig. 1A) revealed 2 restricted bands in the γ region, identified by immunofixation (IFE)3 electrophoresis (Fig. 1B) as IgG κ proteins. The combined concentration of these 2 bands was |
| Databáze: | OpenAIRE |
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