Internal motions of native lysozyme are more organized than those of mutants: a principal component analysis of molecular dynamics data
| Autor: | Reino Laatikainen, Janne T. A. Saarela, Kari Tuppurainen, Tommi Hassinen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
chemistry.chemical_classification
Chemistry education Organic Chemistry Mutant Egg Proteins Biophysics Egg protein Biochemistry Molecular dynamics chemistry.chemical_compound Structure-Activity Relationship Enzyme Principal component analysis Mutation Animals Thermodynamics Muramidase Lysozyme Peptide sequence Chickens health care economics and organizations |
| Zdroj: | Biophysical chemistry. 73(1-2) |
| ISSN: | 0301-4622 |
| Popis: | Principal component analysis (PCA) of molecular dynamics simulations of hen egg white lysozyme and its mutants indicate that even small changes in the amino acid sequence alter considerably the internal molecular motions and that the internal motions are more organized in the native enzyme than in the mutants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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