Iron Leads to Memory Impairment that is Associated with a Decrease in Acetylcholinesterase Pathways
| Autor: | Carla Denise Bonan, Arethuza S. Dornelles, Gustavo Vedana, Maria Noêmia Martins de Lima, Rosane Souza da Silva, Vinicius Pieta Perez, Maurício Reis Bogo, Nadja Schröder |
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| Předmět: |
Male
medicine.medical_specialty Administration Oral Striatum Muscarinic Agonists Gene Expression Regulation Enzymologic Statistics Nonparametric Cellular and Molecular Neuroscience chemistry.chemical_compound Developmental Neuroscience Pregnancy Internal medicine Neural Pathways Reaction Time medicine Galantamine Oxotremorine Animals Memory impairment Drug Interactions Ferrous Compounds Cognitive decline Memory Disorders Dose-Response Relationship Drug Brain Recognition Psychology acetylcholinesterase medicine.disease Acetylcholinesterase Rats Endocrinology Animals Newborn Neurology chemistry Exploratory Behavior Cholinergic Female Cholinesterase Inhibitors Alzheimer's disease Psychology Neuroscience medicine.drug |
| Zdroj: | ResearcherID Repositório Institucional PUCRS Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
| Popis: | Increasing evidence indicates that excessive iron in selective regions of the brain may be involved in the etiology of neurodegenerative disorders. Accordingly, increased levels of iron have been described in brain regions of patients in Parkinson's and Alzheimer's diseases. We have characterized neonatal iron loading in rodents as a novel experimental model that mimics the brain iron accumulation observed in patients with neurodegenerative diseases and produces severe cognitive impairment in the adulthood. In the present study we have investigated the involvement of the cholinergic system on iron-induced memory impairment. The effects of a single administration of the acetylcholinesterase (AChE) inhibitor galantamine or the muscarinic receptor agonist oxotremorine on iron-induced memory deficits in rats were examined. Male Wistar rats received vehicle or iron (10.0 mg/kg) orally at postnatal days 12 to 14. At the age of 2-3 months, animals were trained in a novel object recognition task. Iron-treated rats showed long-term impairments in recognition memory. The impairing effect was reversed by systemic administration of galantamine (1 mg/kg) immediately after training. In addition, iron-treated rats that received oxotremorine (0.5 mg/kg) showed enhanced memory retention. Rats given iron showed a decreased AChE activity in the striatum when compared to controls. The results suggest that, at least in part, iron-induced cognitive deficits are related to a dysfunction of cholinergic neural transmission in the brain. These findings might have implications for the development of novel therapeutic strategies aimed at ameliorating cognitive decline associated with neurodegenerative disorders. |
| Databáze: | OpenAIRE |
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