Antithyroid Antibodies: Their Utilization in the Investigation of Antigenic Thyroid Substances in Material Obtained by Cytologic Aspiration
| Autor: | Pedro Paseyro, Osvaldo F. Grosso, Julio Morató-Manaro, Etna Negrin |
|---|---|
| Rok vydání: | 1963 |
| Předmět: |
endocrine system
medicine.medical_specialty Pathology Goiter endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Thyroid Gland Biochemistry Antibodies Thyroiditis Endocrinology Internal medicine Biopsy Humans Medicine Hashimoto Disease Thyroid Neoplasms medicine.diagnostic_test business.industry Carcinoma Biochemistry (medical) Thyroid Antibody titer medicine.disease Precipitin Tests Carcinoma Papillary medicine.anatomical_structure Pulmonary aspiration Granuloma business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 23:387-390 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-23-4-387 |
| Popis: | Antigenic thyroid substances have been investigated by agar diffusion techniques. Human thyroid antibodies obtained experimentally in the rabbit by the immunity granuloma were used. The same result is achieved by using human serum with a high antithyroid antibody titer obtained from patients with Hashimoto's disease. To obtain the antigenic material for the immunologic investigation, the cytologic aspiration method was used. In all those cases in which the aspirated material contained thyroid colloid, the result was positive, as observed in various types of goiter, papillary carcinoma and metastases from papillary carcinoma. By contrast, it was negative when neither colloid nor differentiated cells were present, as in undifferentiated carcinoma, lymphosarcoma, lymphomatous goiter with extensive replacement of parenchyma, thyroglossal cysts, and suppurative thyroiditis occurring in a pre-existing thyroid nodule. The method under consideration permits the diagnosis of metastases of papillary carcinoma befor... |
| Databáze: | OpenAIRE |
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