Differences in the Immune Response of the Nonmetastatic Axillary Lymph Nodes between Triple-Negative and Luminal A Breast Cancer Surrogate Subtypes
| Autor: | Júlia Casanova Ribes, Joan Francesc García-Fontgivell, Gloria Bueno, Marta Berenguer, Salomé Martínez González, Montserrat Llobera, Ramon Bosch, Jordi Baucells, Carlos López, Lukasz Roszkowiak, Albert Roso, Marcial García-Rojo, Anna Korzynska, Albert Gibert-Ramos, Marylène Lejeune, Esther Sauras Colón, Andrea Gras Navarro, Laia Fontoura |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Axillary lymph nodes Proliferation index Triple Negative Breast Neoplasms Pathology and Forensic Medicine Immune tolerance 03 medical and health sciences 0302 clinical medicine Immune system Breast cancer medicine Humans Retrospective Studies business.industry Immunity Middle Aged medicine.disease Prognosis Primary tumor 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Lymphatic Metastasis Axilla Cancer research Immunohistochemistry Female Lymph Nodes business CD8 Follow-Up Studies |
| Zdroj: | The American journal of pathology. 191(3) |
| ISSN: | 1525-2191 |
| Popis: | Breast cancer (BC) comprises four immunohistochemical surrogate subtypes of which triple-negative breast cancer (TNBC) has the highest risk of mortality. Axillary lymph nodes (ALNs) are the regions where BC cells first establish before distant metastasis, and the presence of tumor cells in the ALN causes an immune tolerance profile that contrasts with that of the nonmetastatic ALN (ALN−). However, few studies have compared the immune components of the ALNs− in BC subtypes. The present study aimed to determine whether differences between immune populations in the primary tumor and ALNs− were associated with the luminal A or TNBC subtype. We evaluated a retrospective cohort of 144 patients using paraffin-embedded biopsies. The TNBC samples tended to have a higher histologic grade and proliferation index and had higher levels of immune markers compared with luminal A in primary tumors and ALNs−. Two methods for validating the multivariate analysis found that histologic grade, intratumoral S100 dendritic cells, and CD8 T lymphocytes and CD57 natural killer cells in the ALNs− were factors associated with TNBC, whereas CD83 dendritic cells in the ALNs− were associated with the luminal A subtype. In conclusion, we found that intratumoral regions and ALNs− of TNBC contained higher concentrations of markers related to immune tolerance than luminal A. This finding partially explains the worse prognosis of patients with TNBC. |
| Databáze: | OpenAIRE |
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