Protein Expression of Matriptase and its Cognate Inhibitor HAI-1 in Human Prostate Cancer
| Autor: | Jens C. Eickhoff, Wei Huang, David Frazier Jarrard, Miranda Warren, Matthew Twohig, Thomas Pier, Chen-Yong Lin |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
PCA3 Pathology medicine.medical_specialty Histology Prostate Diseases Proteinase Inhibitory Proteins Secretory Pathology and Forensic Medicine Automation Prostate cancer Prostate medicine Humans Matriptase Diagnosis Computer-Assisted Neoplasm Metastasis Cell Proliferation Tissue microarray biology business.industry Serine Endopeptidases Prostatic Neoplasms Cancer Epithelial Cells Hyperplasia medicine.disease Medical Laboratory Technology medicine.anatomical_structure Tissue Array Analysis Disease Progression Cancer research biology.protein business |
| Zdroj: | Applied Immunohistochemistry & Molecular Morphology. 17:23-30 |
| ISSN: | 1541-2016 |
| DOI: | 10.1097/pai.0b013e31817c3334 |
| Popis: | Recent studies have suggested that matriptase, a transmembrane serine protease and its cognate inhibitor hepatocyte growth factor activator inhibitor-1 (HAI-1) are important in the progression of many cancers. Limited quantitative data are available on these proteins in prostate cancer. To validate the roles of matriptase and HAI-1 in prostate cancer and its progression, a prostate cancer tissue microarray was constructed. The tissue microarray includes 41 localized prostate cancers (Pca_local), 18 aggressive prostate cancers, 18 metastatic prostate cancers, 24 benign prostate hyperplasias, 18 high-grade intraepithelial neoplasias (HGPIN), and 41 benign prostate tissues. The cellular expression levels of matriptase and HAI-1 were quantified using automated quantitative analysis. We found that matriptase expression levels were significantly higher in Pca_local (P |
| Databáze: | OpenAIRE |
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