Targeted Chemoradiotherapy of Prostate Cancer Using Gold Nanoclusters with Protease Activatable Monomethyl Auristatin E

Autor:	Dong Luo, Xinning Wang, Ethan Walker, Sarah Springer, Gopalakrishnan Ramamurthy, Clemens Burda, James P. Basilion
Rok vydání:	2022
Předmět:	Male Cell Line Tumor Humans Prostatic Neoplasms General Materials Science Chemoradiotherapy Gold urologic and male genital diseases Oligopeptides Xenograft Model Antitumor Assays Article Peptide Hydrolases
Zdroj:	ACS Appl Mater Interfaces
ISSN:	1944-8252 1944-8244
Popis:	Combined radiotherapy (RT) and chemotherapy are prescribed to patients with advanced prostate cancer (PCa) to increase their survival; however, radiation-related side effects and systematic toxicity caused by chemotherapeutic drugs are unavoidable. To improve the precision and efficacy of concurrent RT and chemotherapy, we have developed a PCa-targeted gold nanocluster radiosensitizer conjugated with a highly potent cytotoxin, monomethyl auristatin E, PSMA-AuNC-MMAE, for RT and chemotherapy of PCa. This approach resulted in enhanced uptake of NCs by PSMA-positive cancer cells, targeted chemotherapy, and increased efficacy of RT both in vitro and in vivo. In addition, the combination of gold and MMAE further increased the efficacy of either of the agents delivered alone or simultaneously but not covalently linked. The PSMA-AuNC-MMAE conjugates improve the specificity and efficacy of radiation and chemotherapy, potentially reducing the toxicity of each therapy and making this an attractive avenue for clinical treatment of advanced PCa.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8b0a0f63489f820241c61191f7f47b https://doi.org/10.1021/acsami.1c23780 Zobrazit plný text záznamu