Sulodexide prevents peripheral nerve damage in streptozotocin induced diabetic rats
| Autor: | Chang Ho Song, Hong Sun Baek, Tae Sun Park, Ji Hae Choi, Sun Kyung Song, Wei Jing Liu, Heung Yong Jin, Kyung Ae Lee |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Blood Glucose
Pain Threshold medicine.medical_specialty Kidney Cortex Urology Nerve fiber Cell Count Diabetes Mellitus Experimental Rats Sprague-Dawley Nerve Fibers Oral administration Diabetes mellitus medicine Animals Peripheral Nerves Myelin Sheath Glycosaminoglycans Skin Pharmacology Proteinuria business.industry Superoxide Dismutase Body Weight Electric Conductivity Peripheral Nervous System Diseases Streptozotocin medicine.disease Sulodexide Sciatic Nerve Axons Surgery Rats medicine.anatomical_structure Peripheral neuropathy Gastric Mucosa Regional Blood Flow Female Sciatic nerve medicine.symptom Epidermis business medicine.drug |
| Zdroj: | European journal of pharmacology. 674(2-3) |
| ISSN: | 1879-0712 |
| Popis: | We investigated whether sulodexide has additional protective effects against peripheral nerve damage caused by microvascular dysfunction in a rat model of diabetes. Female Sprague-Dawley (SD) rats were divided into the following 4 groups (n=7-9/group): Normal, Normal+Sulodexide (sulodexide 10mg/kg), diabetic group, and diabetic+Sulodexide (sulodexide 10mg/kg). We assessed current perception threshold, skin blood flow, superoxide dismutase, and proteinuria in experimental rats after oral administration of sulodexide for 20 weeks. We also performed morphometric analysis of sciatic nerves and intraepidermal nerve fibers of the foot. Superoxide dismutase activity in the blood and sciatic nerve were increased significantly after sulodexide treatment in the diabetic group. Current perception threshold was reduced at 2000 Hz (633.3 ± 24.15 vs 741.2 ± 23.5 μA, P |
| Databáze: | OpenAIRE |
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