Effect of Hypovitaminosis D on Lipid Profile in Hypothyroid Patients in Saudi Arabia

Autor: Ayaz Khurram Mallick, Salah A. Sheweita, Ayyub Patel, Mohammed A. Alzahrani, Safar A. Alsaleem, Awad S. Alsamghan
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Aging
endocrine system diseases
medicine.medical_treatment
Thyrotropin
Physiology
030204 cardiovascular system & hematology
Biochemistry
Body Mass Index
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Vitamin D
medicine.diagnostic_test
General Medicine
Middle Aged
Lipids
Lipoproteins
LDL
Cholesterol
Female
Research Article
Adult
Vitamin
endocrine system
Article Subject
Saudi Arabia
Enzyme-Linked Immunosorbent Assay
030209 endocrinology & metabolism
03 medical and health sciences
Hypothyroidism
medicine
Vitamin D and neurology
Humans
Risk factor
Triglycerides
Retrospective Studies
QH573-671
business.industry
Retrospective cohort study
Cholesterol
LDL
Cell Biology
Vitamin D Deficiency
medicine.disease
Steroid hormone
chemistry
business
Lipid profile
Cytology
Dyslipidemia
Hormone
Zdroj: Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Oxidative Medicine and Cellular Longevity
ISSN: 1942-0994
1942-0900
Popis: Background. Hypothyroidism is believed to be associated with dyslipidemia and is considered a risk factor for the development of atherosclerotic cardiovascular diseases (ASCVD). Vitamin D, due to its steroid hormone action, retains cell function and controls the metabolism of lipids. Therefore, the present study was carried out to show the association of the risk factors of ASCVD and deficiency of thyroid hormones and vitamin D levels since no previous studies have been performed on Saudi patients before. Methodology. A retrospective cohort study was carried out on 400 hypothyroid patients. Medical records of those patients were followed up and were classified as normal and hypothyroid patients according to their thyroid-stimulating hormone levels. TSH, vitamin D, and lipid profiles were determined using the ELISA technique. Result. Total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels were significantly higher in hypothyroid patients than those in the normal group. We have found a significant correlation between TSH levels and the risk factors of ASCVD (total cholesterol, triglycerides, and LDL-C). Moreover, a significant correlation between vitamin D levels and the risk factors of ASCVD (total cholesterol, triglycerides, and LDL-C) has been found. In addition, there is a correlation between deficiency of Vit D and low-TSH levels (95% CI 1.092–4.05) indicating a higher risk for the development of ASCVD among those patients. Conclusion. Hypothyroid and vitamin D-deficient patients must be screened regularly at an early stage to predict and also to prevent cardiovascular diseases. Moreover, an adequate supply of vitamin D and TH should be given to those patients to prevent cardiovascular diseases at an early stage.
Databáze: OpenAIRE
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