Pharmacokinetic and pharmacodynamic properties of long-acting insulin analogue NN304 in comparison to NPH insulin in humans
| Autor: | Thomas R. Pieber, Gerald Sendlhofer, Gernot Brunner, M. Ellmerer, S. Hirschberger, G. J. Krejs, A. Wutte, Andrea Siebenhofer, B. Søgaard |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Dose Endocrinology Diabetes and Metabolism medicine.medical_treatment Insulin Isophane NPH insulin Placebo Placebos Endocrinology Double-Blind Method Insulin Detemir Pharmacokinetics Diabetes mellitus Internal medicine Internal Medicine medicine Humans Insulin Serum Albumin Cross-Over Studies business.industry Area under the curve General Medicine medicine.disease Insulin Long-Acting Kinetics Pharmacodynamics Carrier Proteins business |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 108:100-105 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-2000-5887 |
| Popis: | NN304 is a long-acting insulin analogue that is acylated with a 14-C-fatty acid chain. Protraction of action of this novel insulin analogue is due not to slow absorption after subcutaneous administration but to reversible binding to albumin. We investigated the pharmacokinetic and pharmacodynamic properties of insulin analogue NN304 (0.3 and 0.6 U/kg) in comparison to NPH insulin (0.3 and 0.6 IU/kg) in 10 healthy volunteers performing a randomised, double-blind, cross-over, placebo-controlled glucose clamp study. During the observation period of 24 hours the areas under the insulin curve for NPH[0.3 IU/kg] vs. NPH[0.6 IU/kg] were 60 vs. 102 nmol min l(-1) (p |
| Databáze: | OpenAIRE |
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