A retrospective evaluation of the inflammatory marker C-reactive protein (CRP), cholesterol and high-density lipoproteins in patients with major depression: Preliminary findings
| Autor: | R La Rovere, R.M. Salerno, Carla Cotellessa, Chiara Conti, Daniela Campanella, D. Ceddia, L. Marchionni, Domenico De Berardis, Alessandro Valchera, Gabriele Salini, S. Spinella, Gianna Sepede, Enrico Mancini, Filippo Maria Ferro, Alessandro Carano, E. Calcagni, Barbara Scorrano, Francesco Gambi |
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| Předmět: |
030213 general clinical medicine
medicine.medical_specialty Immunology High density lcsh:Medicine 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Internal medicine Total cholesterol Inflammatory marker mental disorders medicine Immunology and Allergy In patient Depression (differential diagnoses) biology Cholesterol business.industry C-reactive protein lcsh:R Endocrinology chemistry biology.protein lipids (amino acids peptides and proteins) business |
| Zdroj: | Scopus-Elsevier European Journal of Inflammation, Vol 3 (2005) |
| Popis: | The aim of this study was to retrospectively evaluate the role of C-reactive protein, total cholesterol and high-density lipoprotein cholesterol in patients suffering from Major Depression (MD). Data of C-reactive protein, total cholesterol (TC) and high-density lipoprotein cholesterol of 37 adult outpatients (17 men, 20 women) with a DSM-IV diagnosis of MD were analyzed. Depression was measured with the 17-item Hamilton Depression Rating Scale (HAM-D) and with the Beck Depression Inventory (BDI). Suicide risk was evaluated with the Scale of Suicide Ideation (SSI). Patients with a lifetime history of attempted suicide were categorized as having higher suicide risk. Higher suicide risk patients showed higher C-reactive protein levels and lower high-density lipoprotein cholesterol levels than lower suicide risk patients whereas total cholesterol levels were not statistically different. C-reactive protein positively correlated with BDI, HAM-D, SSI scores and with number of previous depressive episodes. High-density lipoprotein cholesterol correlated inversely with BDI, HAM-D and SSI scores, whereas, no significant correlations were found between Total Cholesterol and other variables including C-reactive protein. In linear regression models, C-reactive protein was predictor of more severe depression and increased suicide risk. Lower high-density lipoprotein cholesterol levels were significantly predictive of increased suicide risk. |
| Databáze: | OpenAIRE |
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