The limitations of some European healthcare databases for monitoring the effectiveness of Pregnancy Prevention Programmes as risk minimisation measures
| Autor: | Kari Klungsøyr, Helen Dolk, Marlene Sinclair, V Bettoli, Aurora Puccini, Anders Engeland, Daniel Thayer, Rachel Charlton, H. J. Bos, Anna Pierini, Anne Vinkel Hansen, Amanda J. Neville, L. T. W. De Jong-Van Den Berg, Sue Jordan, Ester Garne, Rosa Gini |
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| Přispěvatelé: | PharmacoTherapy, -Epidemiology and -Economics |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pregnancy test
Program evaluation Time Factors Databases Factual Pregnancy Tests computer.software_genre Risk Assessment 030226 pharmacology & pharmacy Minimisation (clinical trials) 03 medical and health sciences 0302 clinical medicine Risk Factors Pregnancy Health care Journal Article Data Mining Electronic Health Records Humans Medicine Electronic health records Pharmacology (medical) 030212 general & internal medicine Pregnancy prevention programme Medical prescription Isotretinoin Pharmacology Data collection Database business.industry Abnormalities Drug-Induced Pregnancy Unplanned Abortion Induced General Medicine IADB medicine.disease Teratogen Europe Contraception Teratogens Patient Compliance Female Medical Record Linkage business Risk assessment computer Program Evaluation |
| Zdroj: | Charlton, R, Bettoli, V, Bos, H J, Engeland, A, Garne, E, Gini, R, Hansen, A, de Jong-van den Berg, L, Jordan, S, Klungsøyr, K, Neville, A, Pierini, A, Puccini, A, Sinclair, M, Thayer, D & Dolk, H 2018, ' The limitations of some European healthcare databases for monitoring the effectiveness of Pregnancy Prevention Programmes as risk minimisation measures ', European Journal of Clinical Pharmacology, vol. 74, no. 4, pp. 513-520 . https://doi.org/10.1007/s00228-017-2398-9 European Journal of Clinical Pharmacology, 74(4), 513-520. Springer Verlag Charlton, R A, Bettoli, V, Bos, H J, Engeland, A, Garne, E, Gini, R, Hansen, A V, de Jong-van den Berg, L T W, Jordan, S, Klungsøyr, K, Neville, A J, Pierini, A, Puccini, A, Sinclair, M, Thayer, D & Dolk, H 2018, ' The limitations of some European healthcare databases for monitoring the effectiveness of pregnancy prevention programmes as risk minimisation measures ', European Journal of Clinical Pharmacology, vol. 74, no. 4, pp. 513-520 . https://doi.org/10.1007/s00228-017-2398-9 |
| ISSN: | 0031-6970 |
| Popis: | PURPOSE: Pregnancy prevention programmes (PPPs) exist for some medicines known to be highly teratogenic. It is increasingly recognised that the impact of these risk minimisation measures requires periodic evaluation. This study aimed to assess the extent to which some of the data needed to monitor the effectiveness of PPPs may be present in European healthcare databases.METHODS: An inventory was completed for databases contributing to EUROmediCAT capturing pregnancy and prescription data in Denmark, Norway, the Netherlands, Italy (Tuscany/Emilia Romagna), Wales and the rest of the UK, to determine the extent of data collected that could be used to evaluate the impact of PPPs.RESULTS: Data availability varied between databases. All databases could be used to identify the frequency and duration of prescriptions to women of childbearing age from primary care, but there were specific issues with availability of data from secondary care and private care. To estimate the frequency of exposed pregnancies, all databases could be linked to pregnancy data, but the accuracy of timing of the start of pregnancy was variable, and data on pregnancies ending in induced abortions were often not available. Data availability on contraception to estimate compliance with contraception requirements was variable and no data were available on pregnancy tests.CONCLUSION: Current electronic healthcare databases do not contain all the data necessary to fully monitor the effectiveness of PPP implementation, and thus, special data collection measures need to be instituted. |
| Databáze: | OpenAIRE |
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