Effects of a New Human Recombinant MnSOD in the Treatment of Photoaging and Actinic Keratosis
| Autor: | Aldo Mancini, Antonietta Schiattarella, Maria Grazia Ruggiero, Maria Laura Pollio, Antonella Borrelli, Patrizia Forgione, Alessandra Pica |
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| Přispěvatelé: | RUGGIERO MARIA, Grazia, POLLIO MARIA, Laura, Schiattarella, Antonietta, Borrelli, Antonella, Mancini, Aldo, Pica, Alessandra, Forgione, P. A. T. R. I. Z. I. A. |
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Reactive oxygen species Antioxidant Cellular respiration business.industry Photoaging medicine.medical_treatment Actinic keratosis medicine.disease Dermatology Manganese Superoxide Dismutase law.invention chemistry law actinic keratosis Recombinant DNA Cancer research Medicine Skin lesion business Recombinant Mn-superoxide dismutase rMnsod Skin |
| Zdroj: | Journal of Cancer Therapy. :56-59 |
| ISSN: | 2151-1942 2151-1934 |
| DOI: | 10.4236/jct.2013.46a1009 |
| Popis: | Physiological processes, as aerobic metabolism and inflammatory response, generate reactive oxygen species (ROS) that may induce cellular injury when their amount is increased and antioxidant defense mechanisms are overwhelmed. Also, ROS are generated following UV skin irradiation able to deplete the natural antioxidant defenses in the skin. The increase in exposure to UV may lead to photoaging and precancerous skin lesions (actinic keratosis). New antioxidant strategies in the prevention and therapy of skin lesions are urgently needed. In this study, we evaluated the antioxidant efficacy of a recombinant form of human manganese superoxide dismutase able to inhibit reactive oxygen species pro- duction in some patients affected by severe photoaging and actinic keratosis |
| Databáze: | OpenAIRE |
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