Pre-Morbid Risk Factors for Amyotrophic Lateral Sclerosis: Prospective Cohort Study
| Autor: | Catharine R. Gale, George David Batty |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
amyotrophic lateral sclerosis
UK Biobank Pediatrics medicine.medical_specialty Epidemiology business.industry Hazard ratio Confounding Short Report medicine.disease Biobank Confidence interval Case fatality rate Etiology cohort study medicine risk factors Clinical Epidemiology Amyotrophic lateral sclerosis Prospective cohort study business Psychosocial Cohort study |
| Zdroj: | Clinical Epidemiology |
| ISSN: | 1179-1349 |
| DOI: | 10.2147/clep.s329521 |
| Popis: | BackgroundAs a neurodegenerative disorder with high case-fatality, there is a need to identify primary, modifiable risk factors for amyotrophic lateral sclerosis (ALS). Their detection has, however, proved elusive and this may be ascribed to the scarcity of well-characterised, sufficiently-powered cohort studies necessary to explore the aetiology of this rare condition.MethodsUK Biobank is an on-going, closed, prospective cohort study in which 502,524 participants (273,420 women) have been linked to national hospital and mortality registries. Baseline data collection took place between 2006 and 2010 when a range of psychosocial, physiological, and demographic data were captured.ResultsApproximately 11 years of event surveillance gave rise to 301 hospitalisations and 279 deaths ascribed to ALS. After left censoring to account for reverse causality and adjustment for confounding factors, being older (hazard ratio per 10 year increase; 95% confidence interval: 1.92; 1.58, 2.33) and male (1.37; 1.00, 1.87) were associated with elevated rates of hospitalisation for ALS. Similar effects were apparent when death due to the disorder was the outcome of interest. Of the remaining 23 potential risk indices, however, there was only a suggestion that taller people experienced an increased risk of hospitalisation (per SD increase: 1.31; 1.09, 1.59).ConclusionsIn the present study, a comprehensive array of potential risk indices were essentially unrelated to later ALS. |
| Databáze: | OpenAIRE |
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