Prognostic Value of High-sensitivity Troponin I in Patients with Septic Shock: A Prospective Observational Study
| Autor: | Ilhem Boutiba, Ali Jendoubi, Salma Jerbi, Lamia Kanzari, Ahmed Abbess, Mohamed Houissa, Salma Ghedira, Elaa Maamar, Zied Samoud |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Mean arterial pressure medicine.medical_treatment Renal function Critical Care and Intensive Care Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine Septic shock Troponin I medicine Mortality Prospective cohort study Mechanical ventilation biology business.industry 030208 emergency & critical care medicine medicine.disease Prognosis Troponin 030228 respiratory system SAPS II High-sensitivity cardiac troponin Cardiology biology.protein Original Article business |
| Zdroj: | Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine |
| ISSN: | 1998-359X 0972-5229 |
| Popis: | Background Myocardial dysfunction is one of the mechanisms involved in the pathophysiology of septic shock. The role of troponin as a surrogate of myocardial injury in septic shock is still debated. The aim of this study was to assess the prognostic value of high-sensitivity cardiac troponin I (hs-cTnI) assay in predicting 28-day mortality in patients with septic shock. Materials and Methods Prospective study including 75 patients with septic shock admitted to a medico-surgical ICU from January to December 2017. Patients under the age of 18 years, known pregnancy and patients in post–cardiac arrest were excluded. Clinical and demographic data including age, gender, comorbidities, SAPS II and SOFA scores were collected. Hs-cTnI was measured soon after admission and 12, 24, 48 and 72 after. Receiver operating characteristic (ROC) analysis was performed to identify the most useful troponin I cut-off level for the prediction of 28-day mortality. A p |
| Databáze: | OpenAIRE |
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