The Granule Porosity Controls the Loss of Compactibility for Both Dry- and Wet-Processed Cellulose Granules but at Different Rate
| Autor: | Göran Alderborn, Josefina Nordström |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Materials science
Granule (cell biology) Compaction Pharmaceutical Science Friability Excipients Microcrystalline cellulose Granulation chemistry.chemical_compound Tableting chemistry Tensile Strength Ultimate tensile strength Technology Pharmaceutical Powders Composite material Cellulose Porosity Tablets |
| Zdroj: | Journal of Pharmaceutical Sciences. 104:2029-2039 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.24439 |
| Popis: | The aim of this study was to investigate the role of porosity on the compression behavior and tablet tensile strength for granules produced by a dry granulation procedure. Microcrystalline cellulose was used as a typical pharmaceutical excipient and a comparison was made with the effect of granule porosity on the compression behavior and tablet tensile strength of wet-processed granules of the same composition. Both the wet and dry granulation process caused a loss in compactibility of the material that was controlled by the granule porosity up to a critical point of porosity and friability. Above this threshold value of porosity, the granules nearly collapsed completely into primary particles during compression. In these cases, the micro-structure and tensile strength of the formed tablets resembled that of tablets formed from the original ungranulated powder. |
| Databáze: | OpenAIRE |
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