Independent Lineages of Highly Sulfadoxine-ResistantPlasmodium falciparumHaplotypes, Eastern Africa
| Autor: | Whitney E. Harrington, Stephen J. Rogerson, Ebbie Chaluluka, Linda Kalilani-Phiri, Morgan M. Goheen, Steven R. Meshnick, Mwayi Madanitsa, Antoinette Tshefu, Edward Kabyemela, Steve M. Taylor, Alejandro L. Antonia, Victor Mwapasa, Carole Khairallah, Feiko O. ter Kuile, Michal Fried, Patrick E. Duffy |
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| Přispěvatelé: | Other departments |
| Rok vydání: | 2014 |
| Předmět: |
Malawi
lineages haplotypes Epidemiology medicine.medical_treatment lcsh:Medicine population DHPS Pregnancy genetics Malaria Falciparum wb_330 eastern Africa Genetics wc_770 education.field_of_study Africa Eastern Infectious Diseases Female sulfadoxine Microbiology (medical) Sulfadoxine Plasmodium falciparum Population malaria qv_38 parasites Biology lcsh:Infectious and parasitic diseases qw_45 Antimalarials parasitic diseases medicine Humans lcsh:RC109-216 education Dihydropteroate Synthase Pregnancy-associated malaria drug resistance Research lcsh:R Haplotype medicine.disease biology.organism_classification Virology wc_750 Cross-Sectional Studies qx_135 Mutation Dihydropteroate synthase Malaria Microsatellite Repeats |
| Zdroj: | Emerging infectious diseases, 20(7), 1140-1148. Centers for Disease Control and Prevention (CDC) Emerging Infectious Diseases Emerging Infectious Diseases, Vol 20, Iss 7, Pp 1140-1148 (2014) |
| ISSN: | 1080-6059 1080-6040 |
| DOI: | 10.3201/eid2007.131720 |
| Popis: | Parasites with increased resistance to sulfadoxine might undermine malaria control measures. Sulfadoxine-resistant Plasmodium falciparum undermines malaria prevention with sulfadoxine/pyrimethamine. Parasites with a highly resistant mutant dihydropteroate synthase (dhps) haplotype have recently emerged in eastern Africa; they negated preventive benefits of sulfadoxine/pyrimethamine, and might exacerbate placental malaria. We explored emerging lineages of dhps mutant haplotypes in Malawi, the Democratic Republic of the Congo, and Tanzania by using analyses of genetic microsatellites flanking the dhps locus. In Malawi, a triple-mutant dhps SGEG (mutant amino acids are underlined) haplotype emerged in 2010 that was closely related to pre-existing double-mutant SGEA haplotypes, suggesting local origination in Malawi. When we compared mutant strains with parasites from the Democratic Republic of the Congo and Tanzania by multiple independent analyses, we found that SGEG parasites were partitioned into separate lineages by country. These findings support a model of local origination of SGEG dhps haplotypes, rather than geographic diffusion, and have implications for investigations of emergence and effects of parasite drug resistance. |
| Databáze: | OpenAIRE |
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