African-American and Caucasian participation in postmortem human brain donation for neuropsychiatric research
| Autor: | Constance DiAngelo, Stephen B. Thomas, Joel E. Kleinman, Amy Deep-Soboslay, Thomas M. Hyde, Michelle I. Mighdoll, Mary M. Herman, Dawn Zulauf, David R. Fowler, Jewell P. King, Andrew E. Jaffe, Jonathan Sirovatka |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Biomedical Research Autopsy Neuropsychiatry Alzheimer's Disease 0302 clinical medicine Medicine and Health Sciences Ethnicities African American people Referral and Consultation 0303 health sciences Brain Diseases Multidisciplinary Medical examiner Brain Neurodegenerative Diseases Middle Aged Population groupings Telephones Tissue Donors Substance abuse Suicide Neurology Donation Medicine Engineering and Technology Female Anatomy Research Article medicine.medical_specialty Science MEDLINE Equipment Resistance (psychoanalysis) Surgical and Invasive Medical Procedures White People 03 medical and health sciences Tissue Donation Mental Health and Psychiatry medicine Humans Family 030304 developmental biology Communication Equipment business.industry Biology and Life Sciences medicine.disease Black or African American Family medicine Postmortem Changes Dementia People and places business 030217 neurology & neurosurgery |
| Zdroj: | PLoS ONE PLoS ONE, Vol 14, Iss 10, p e0222565 (2019) |
| ISSN: | 1932-6203 |
| Popis: | Increased African-American research participation is critical to the applicability and generalizability of biomedical research, as population diversity continues to increase both domestically and abroad. Yet numerous studies document historical origins of mistrust, as well as other barriers that may contribute to resistance in the African-American community towards participation in biomedical research. However, a growing body of more recent scientific evidence suggests that African-Americans value research and are willing to participate when asked. In the present study, we set out to determine factors associated with research participation of African-American families in postmortem human brain tissue donation for neuropsychiatric disorders as compared with Caucasian families, from same-day medical examiner autopsy referrals. We retrospectively reviewed brain donation rates, as well as demographic and clinical factors associated with donation in 1,421 consecutive referrals to three medical examiner's offices from 2010-2015. Overall, 69.7% of all next-of-kin contacted agreed to brain donation. While Caucasian families consented to donate brain tissue at a significantly higher rate (74.1%) than African-American families (57.0%) (p0.05). However, Caucasian donors were significantly older, had more years of education, were more likely to be referred for study due to a psychiatric diagnosis, more likely to have comorbid substance abuse, and more likely to have died via suicide, as compared with African-American donors (p |
| Databáze: | OpenAIRE |
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