Interfacial properties of hydrophilized poly(lactic-co-glycolic acid) layers with various thicknesses
| Autor: | Tivadar Lohner, Miklós Mohai, Cs. B. Pénzes, Gergő Gyulai, Sándor Kurunczi, Éva Kiss, Peter Petrik |
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| Rok vydání: | 2011 |
| Předmět: |
Materials science
Biocompatible Materials Hydrophilization Biomaterials chemistry.chemical_compound Colloid and Surface Chemistry Adsorption Polylactic Acid-Polyglycolic Acid Copolymer Organic chemistry Lactic Acid Drug Carriers technology industry and agriculture Proteins Surfaces Coatings and Films Electronic Optical and Magnetic Materials Polyester PLGA chemistry Chemical engineering Wettability Nanoparticles Surface modification Wetting Drug carrier Polyglycolic Acid Protein adsorption |
| Zdroj: | Journal of Colloid and Interface Science. 362:600-606 |
| ISSN: | 0021-9797 |
| DOI: | 10.1016/j.jcis.2011.06.055 |
| Popis: | Biodegradable polyesters such as poly(lactic-co-glycolic acid) copolymers (PLGA) are preferred materials for drug carrier systems although their surface hydrophobicity greatly limits their use in controlled drug delivery. PLGA thin films on a solid support blended with PEG-containing compound (Pluronic) were used as model systems to study the interfacial interactions with aqueous media. Degree of surface hydrophilization was assessed by wettability, and X-ray photoelectron spectroscopy (XPS) measurements. Protein adsorption behavior was investigated by in situ spectroscopic ellipsometry. The degree of protein adsorption showed a good correlation with the hydrophilicity, and surface composition. Unexpectedly, the layer thickness was found to have a great impact on the interfacial characteristics of the polymer films in the investigated regime (20-200 nm). Thick layers presented higher hydrophilicity and great resistance to protein adsorption. That special behavior was explained as the result of the swelling of the polymer film combined with the partial dissolution of Pluronic from the layer. This finding might promote the rational design of surface modified biocompatible nanoparticles. |
| Databáze: | OpenAIRE |
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