Association of adverse birth outcomes with prenatal uranium exposure: A population-based cohort study
| Autor: | Bin Zhang, Jia Chen, Ke Hao, Shuangshuang Bao, Yuzeng Zhang, Xia Sheng, Shunqing Xu, Aifen Zhou, Wenyu Liu, Yuanyuan Li, Hongxiu Liu, Weiping Zhang, Wei Xia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
China
medicine.medical_specialty 010504 meteorology & atmospheric sciences Birth weight Gestational Age 010501 environmental sciences Logistic regression 01 natural sciences Cohort Studies Pregnancy Birth Weight Humans Medicine lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science lcsh:GE1-350 business.industry Obstetrics Confounding Infant Newborn Pregnancy Outcome Gestational age Radiation Exposure medicine.disease Confidence interval Low birth weight Maternal Exposure Premature Birth Uranium Small for gestational age Female medicine.symptom business |
| Zdroj: | Environment International, Vol 135, Iss, Pp-(2020) |
| ISSN: | 0160-4120 |
| Popis: | Uranium (U) is a well-recognized hazardous heavy metal with embryotoxicity and fetotoxicity. However, little is known about its association with adverse birth outcomes. We aimed to investigate the potential correlation between prenatal U exposure and birth outcomes. Urine samples of 8500 women were collected before delivery from a birth cohort in Wuhan, China. Concentrations of urinary U and other metals were measured by inductively coupled plasma mass spectrometry. We used multivariable logistic regressions to evaluate the associations between urinary U concentrations and adverse birth outcomes, such as preterm birth (PTB), low birth weight (LBW) and small for gestational age (SGA). Associations of urinary U concentrations with gestational age, birth weight, and birth length were investigated by linear regressions. The geometric mean of U concentration was 0.03 μg/L. After adjustment for potential confounders, we found each Log2-unit increase in U concentration was associated with a significant decrease in gestational age [adjusted β = −0.32 day; 95% confidence interval (CI): −0.44, −0.20] and a significant increased likelihood of PTB (adjusted OR = 1.18, 95% CI: 1.07, 1.29). This birth cohort uncovered an association of maternal exposure to U during pregnancy with decreased gestational age and increased risk of PTB. Our findings reveal an association of maternal exposure to U during pregnancy with decreased gestational age and increased risk of PTB. Keywords: Adverse birth outcomes, Gestational age, Prenatal exposure, Preterm birth, Uranium |
| Databáze: | OpenAIRE |
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