Morphologically homogeneous, pH-responsive gold nanoparticles for non-invasive imaging of HeLa cancer
| Autor: | Eun Kyoung Ryu, Yeon Sil Hwang, Dae-Woong Jung, Gi-Ra Yi, Jeong Kyu Bang, Jun Min Kim, Gaehang Lee, Min Su Yim |
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| Rok vydání: | 2021 |
| Předmět: |
Biocompatibility
Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Metal Nanoparticles Uterine Cervical Neoplasms Bioengineering 02 engineering and technology HeLa 03 medical and health sciences Mice Radioligand Assay polycyclic compounds medicine Animals Humans General Materials Science Doxorubicin 030304 developmental biology 0303 health sciences Antibiotics Antineoplastic biology Chemistry Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology biology.organism_classification Xenograft Model Antitumor Assays carbohydrates (lipids) Colloidal gold Positron-Emission Tomography Cancer cell Drug delivery Biophysics Molecular Medicine Female Gold Nanocarriers 0210 nano-technology Linker medicine.drug HeLa Cells |
| Zdroj: | Nanomedicine : nanotechnology, biology, and medicine. 34 |
| ISSN: | 1549-9642 |
| Popis: | Gold nanoparticles (AuNPs) have been widely used as nanocarriers in drug delivery to improve the efficiency of chemotherapy treatment and enhance early disease detection. The advantages of AuNPs include their excellent biocompatibility, easy modification and functionalization, facile synthesis, low toxicity, and controllable particle size. This study aimed to synthesize a conjugated citraconic anhydride link between morphologically homogeneous AuNPs and doxorubicin (DOX) (DOX-AuNP). The carrier was radiolabeled for tumor diagnosis using positron emission tomography (PET). The systemically designed DOX-AuNP was cleaved at the citraconic anhydride linker site under the mild acidic conditions of a cancer cell, thereby releasing DOX. Subsequently, the AuNPs aggregated via electrostatic attraction. HeLa cancer cells exhibited a high uptake of the radiolabeled DOX-AuNP. Moreover, PET tumor images were obtained using radiolabeled DOX-AuNP in cancer xenograft mouse models. Therefore, DOX-AuNP is expected to provide a valuable insight into the use of radioligands to detect tumors using PET. |
| Databáze: | OpenAIRE |
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