Maintenance Impact of Large Dose of Vitamin C on Proinflammatory Cytokines, Insulin, and Electrocardiographic Parameters of Wistar Rats Following Partial Pancreatectomy
| Autor: | O. M. Azeez, Sadudeen Adetayo Amid, K. T. Biobaku, Zubair Salman Abdulkadir |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty 040301 veterinary sciences medicine.medical_treatment Immunology Enzyme-Linked Immunosorbent Assay Ascorbic Acid 030204 cardiovascular system & hematology Proinflammatory cytokine 0403 veterinary science 03 medical and health sciences Electrocardiography 0302 clinical medicine Pancreatectomy Virology Large dose Internal medicine medicine Animals Insulin Vitamin C business.industry Interleukin-6 Interleukin-8 Interleukin Heart 04 agricultural and veterinary sciences Cell Biology Rats Partial Pancreatectomy Endocrinology Models Animal Cytokines Tumor necrosis factor alpha Inflammation Mediators business Wound healing |
| Zdroj: | Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 41(5) |
| ISSN: | 1557-7465 |
| Popis: | We investigated serum tumor necrosis factor alpha (TNF-α) and interleukins (IL-6 and IL-8) in rats undergoing pancreatic wound healing after partial pancreatectomy. In addition, we studied the effects of partial pancreatectomy on the insulin and the electrocardiography (ECG). We proposed that vitamin C (VitC) could have maintenance impact on TNF-α, IL-6, IL-8, insulin, and ECG parameters of pancreatic wound healing of Wistar rats that had partial pancreatectomy surgery, if administered in large dose. Thirty-five male adult Wistar rats (180-250 g) were randomized into 7 groups, with 5 rats in each group. Group 1 was control. Groups 2, 3, and 4 (phase 1) received oral 1,000 mg/kg VitC, while groups 5, 6, and 7 (phase 2) received only water and feed |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|