Photoprotection of maqui berry against ultraviolet B-induced photodamage in vitro and in vivo
| Autor: | Xiao-Shan Meng, Youwei Wang, Ling Chen, Hui-Ying Fu, Gao Zhou, Qigui Mo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Keratinocytes Male Antioxidant DNA damage Cell Survival Ultraviolet Rays medicine.medical_treatment Elaeocarpaceae medicine.disease_cause Nitric Oxide Superoxide dismutase Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Mice 0404 agricultural biotechnology stomatognathic system medicine Animals HaCaT Cells Humans Mice Inbred BALB C integumentary system biology 04 agricultural and veterinary sciences General Medicine Glutathione 040401 food science Molecular biology stomatognathic diseases HaCaT 030104 developmental biology chemistry Photoprotection Fruit biology.protein Powders Oxidative stress Food Science DNA Damage |
| Zdroj: | Foodfunction. 11(3) |
| ISSN: | 2042-650X |
| Popis: | Ultraviolet B (UVB) irradiation-induced DNA damage, oxidative stress, inflammatory processes, and skin pigmentation cause pigmented spots, wrinkles, inflammation, and accelerated skin aging and cancer. Maqui berry (Aristotelia chilensis) is a natural antioxidant, anticancer, and anti-inflammatory food. We investigated the photoprotective properties of the ethyl acetate fraction of maqui berry ethanol extract (MEE) in vitro and in vivo. Spectrophotometric measurements revealed dominant extinction profile of MEE in the UVB range. MEE clearly reversed the DNA damage induced by UVB irradiation in HaCaT cells by upregulating endogenous cellular enzymatic and non-enzymatic antioxidant systems containing superoxide dismutase, catalase, and glutathione and reducing the production of nitric oxide. Moreover, MEE treatment enhanced the antioxidant ability and weakened lipid peroxidation in BALB/c mice exposed to UVB radiation. It also down-regulated interleukin (IL)-6 and tumor necrosis factor-α levels and up-regulated IL-4 levels. Moreover, MEE inhibited the UVB-triggered activation of ERK and p38 MAPK. These data suggest that MEE is an effective agent against UVB-induced photodamage. |
| Databáze: | OpenAIRE |
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