Regulation of Alzheimer β-amyloid precursor trafficking and metabolism11Portions of this review have previously appeared in Trends in Endocrinology and Metabolism and are reprinted here with the permission of Elsevier Publishing
| Autor: | S.E. Gandy, Suzana Petanceska |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Genetics
Regulation of gene expression Trafficking biology medicine.diagnostic_test Amyloid Proteolysis Mutant P3 peptide medicine.disease Metabolism mental disorders medicine Amyloid precursor protein biology.protein Coding region Dementia Molecular Medicine Alzheimer β-amyloid precursor Molecular Biology Regulation |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1502(1):44-52 |
| ISSN: | 0925-4439 |
| DOI: | 10.1016/s0925-4439(00)00031-4 |
| Popis: | Alzheimer’s disease (AD) is characterized by the intracranial accumulation of the 4 kDa amyloid-β peptide (Aβ), following proteolysis of a ∼700-amino acid, integral membrane precursor, the Alzheimer amyloid precursor protein (APP). The best evidence causally linking APP to AD has been provided by the discovery of mutations within the APP coding sequence that segregate with disease phenotypes in autosomal dominant forms of familial AD (FAD). Though FAD is rare ( |
| Databáze: | OpenAIRE |
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