Prevalence, Risk Factors, and Genetic Traits in Metabolically Healthy and Unhealthy Obese Individuals
| Autor: | Evgeny Shlyakhto, Elena Baranova, Tatiana Karonova, E. Bazhenova, Olga Belyaeva, O. Berkovich, A. Berezina, Elena N. Grineva, D. Brovin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Blood Glucose Leptin Male medicine.medical_specialty Waist Article Subject lcsh:Medicine Blood Pressure Biology Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Body Mass Index Russia Risk Factors Internal medicine Genotype Prevalence medicine Humans Insulin Abdominal obesity Obesity Metabolically Benign General Immunology and Microbiology Adiponectin medicine.diagnostic_test lcsh:R General Medicine Middle Aged medicine.disease Lipids Obesity 3. Good health Endocrinology Obesity Abdominal Receptors Leptin Female Waist Circumference medicine.symptom Lipid profile Body mass index Research Article |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2015/548734 |
| Popis: | Objective. To assess prevalence of metabolically healthy individuals among patients with abdominal obesity (AO) and to determine phenotype and potential genetic traits associated with a benign metabolic status.Methods. 503 AO patients without cardiovascular diseases were examined. Waist circumference (WC), BMI, blood pressure, plasma glucose and serum insulin levels, HOMA-IR, lipid profile, and adiponectin (AN) and leptin (LEP) concentrations in serum were measured. Polymorphisms A19G and Q223R of the LEP and LEP receptor gene, and G276T and T45G of the AN gene were investigated.Results. 91.3% of patients were metabolically unhealthy obese (MUO), and 8.7% metabolically healthy obese (MHO). MHO patients were younger, and had lesser BMI and WC, while duration of obesity, frequency, and duration of physical training were greater than MUO patientsp<0.05. In MHO and MUO patients distribution of the G19G, G19A, and A19A genotypes of the LEP gene and G276G, G276T, and T276T genotypes of AN gene did not differ. The Т45Т genotype was associated with increase of metabolic disorders’ risk for patients with АО (OR = 2.331; 95% CI=1.121÷5.132).Conclusions. Prevalence of MHO individuals among patients with AO is low. Benign metabolic status was associated with younger age, lower waist circumference, and higher physical activity, shorter duration of obesity, and G45G adiponectin genotype carriage. |
| Databáze: | OpenAIRE |
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