Structural insights into the 3′-end mRNA maturation machinery: Snapshot on polyadenylation signal recognition
| Autor: | Sébastien Fribourg, Stéphane Thore |
|---|---|
| Přispěvatelé: | Acides Nucléiques : Régulations Naturelle et Artificielle (ARNA), Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ARN : régulations naturelle et artificielle, Université Bordeaux Segalen - Bordeaux 2-Institut Européen de Chimie et de Biologie-Institut National de la Santé et de la Recherche Médicale (INSERM), CCSD, Accord Elsevier |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Signal peptide Polyadenylation Computational biology Cleavage and polyadenylation specificity factor Biology Biochemistry Fungal Proteins 03 medical and health sciences Yeasts Humans Directionality RNA Messenger [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] ComputingMilieux_MISCELLANEOUS 030102 biochemistry & molecular biology Mechanism (biology) MRNA maturation Cleavage And Polyadenylation Specificity Factor SIGNAL (programming language) General Medicine 030104 developmental biology Cleavage Stimulation Factor Snapshot (computer storage) Protein Binding |
| Zdroj: | Biochimie Biochimie, Elsevier, 2019, 164, pp.105-110. ⟨10.1016/j.biochi.2019.03.016⟩ Biochimie, 2019, 164, pp.105-110. ⟨10.1016/j.biochi.2019.03.016⟩ |
| ISSN: | 0300-9084 |
| Popis: | Pre-mRNA 3'-end maturation is achieved by a mechanism requiring four different protein complexes assembled from approximately twenty factors. A global understanding of this essential process is still missing due to the inability to structurally characterize the entire complexes, even though structures of the isolated factors have been obtained. In this review, we summarize recent findings regarding the atomic description of one of the major players, the Cleavage and Polyadenylation Specificity Factor complex (CPSF in human, CPF in yeast). These data provide information on the architecture adopted by the major components of this complex, and on its capacity to recognize the polyadenylation signal sequence. |
| Databáze: | OpenAIRE |
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