Diffusion Properties of Normal-Appearing White Matter Microstructure and Severity of Motor Impairment in Acute Ischemic Stroke
| Autor: | Yurany A. Arevalo, Carson Ingo, Chen Lin, Shyam Prabhakaran, James Higgins |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Internal capsule External capsule Motor Disorders Splenium Neuroimaging Corpus callosum Brain Ischemia 030218 nuclear medicine & medical imaging Diffusion White matter 03 medical and health sciences 0302 clinical medicine Internal medicine Fractional anisotropy Humans Medicine Radiology Nuclear Medicine and imaging Stroke Aged business.industry Adult Brain Middle Aged medicine.disease White Matter Hyperintensity Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Cardiology Anisotropy Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | AJNR Am J Neuroradiol |
| ISSN: | 1936-959X 0195-6108 |
| DOI: | 10.3174/ajnr.a6357 |
| Popis: | BACKGROUND AND PURPOSE: The effect of white matter hyperintensities as measured by FLAIR MR imaging on functional impairment and recovery after ischemic stroke has been investigated thoroughly. However, there has been growing interest in investigating normal-appearing white matter microstructural integrity following ischemic stroke onset with techniques such as DTI. MATERIALS AND METHODS: Fifty-two patients with acute ischemic stroke and 36 without stroke were evaluated with a DTI and FLAIR imaging protocol and clinically assessed for the severity of motor impairment using the Motricity Index within 72 hours of suspected symptom onset. RESULTS: There were widespread decreases in fractional anisotropy and increases in mean diffusivity and radial diffusivity for the acute stroke group compared with the nonstroke group. There was a significant positive association between fractional anisotropy and motor function and a significant negative association between mean diffusivity/radial diffusivity and motor function. The normal-appearing white matter ROIs that were most sensitive to the Motricity Index were the anterior/posterior limb of the internal capsule in the infarcted hemisphere and the splenium of the corpus callosum, external capsule, posterior limb/retrolenticular part of the internal capsule, superior longitudinal fasciculus, and cingulum (hippocampus) of the intrahemisphere/contralateral hemisphere. CONCLUSIONS: The microstructural integrity of normal-appearing white matter is a significant parameter to identify neural differences not only between those individuals with and without acute ischemic stroke but also correlated with the severity of acute motor impairment. |
| Databáze: | OpenAIRE |
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