Colletoic acid, a novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitor from Colletotrichum gloeosporioides SANK 21404

Autor:	Azusa Aoyagi, Megumi Umetani, Ono Yasunori, Mariko Ito-Kobayashi, Toshio Takatsu, Yoji Furukawa, Yasunori Muramatsu, Mizuki Takahashi
Rok vydání:	2008
Předmět:	Models Molecular Magnetic Resonance Spectroscopy Chemical Phenomena Molecular Conformation Dehydrogenase Fungus Cyclopentanes Sesquiterpene Crystallography X-Ray Absolute structure chemistry.chemical_compound Colletoic acid Colletotrichum gloeosporioides 11β-hydroxysteroid dehydrogenase type 1 11-beta-Hydroxysteroid Dehydrogenase Type 2 Drug Discovery 11-beta-Hydroxysteroid Dehydrogenase Type 1 Colletotrichum Humans Spiro Compounds Enzyme Inhibitors Pharmacology biology Dose-Response Relationship Drug Chemistry Physical Esters biology.organism_classification Kinetics chemistry Biochemistry Fermentation biology.protein Sesquiterpenes
Zdroj:	The Journal of antibiotics. 61(3)
ISSN:	0021-8820
Popis:	Colletoic acid, a novel 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor, was found and isolated from the cultured broth of the producing fungus Colletotrichum gloeosporioides SANK 21404. Its structure was determined to be a novel acorene-type sesquiterpene by several spectroscopic methods. The absolute structure of colletoic acid was established using a modified Mosher's method and single-crystal X-ray diffraction analysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc72fa7202a99a7d63e82ba29a5c9657 https://pubmed.ncbi.nlm.nih.gov/18503191 Zobrazit plný text záznamu