Asymmetric Synthesis of Functionalized 9-Methyldecalins Using a Diphenylprolinol-Silyl-Ether-Mediated Domino Michael/Aldol Reaction
| Autor: | Seitaro Koshino, Hugo A. Salazar, Yujiro Hayashi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Silylation
Diphenylprolinol Chemistry organic chemicals education Organic Chemistry Enantioselective synthesis Biochemistry humanities Catalysis Aldol reaction Cascade reaction Intramolecular force polycyclic compounds Michael reaction medicine Organic chemistry heterocyclic compounds Physical and Theoretical Chemistry medicine.drug |
| Zdroj: | Organic Letters. 23:6654-6658 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.1c02196 |
| Popis: | Substituted 9-methyldecalin derivatives containing an all carbon quaternary chiral center were synthesized with excellent enantioselectivity via an organocatalyst-mediated domino reaction. The first reaction is a diphenylprolinol silyl ether-mediated Michael reaction, and the second reaction is an intramolecular aldol reaction. The enantiomerically pure catalyst is involved in both reactions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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