Inhibition of platelet aggregability by moderate-intensity physical exercise: a randomized clinical trial in overweight men
| Autor: | M Ihanainen, Jukka T. Salonen, Kari Seppänen, V Rissanen, Riitta Salonen, Rainer Rauramaa, Juha M. Venäläinen |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Time Factors Platelet Aggregation Population Physical Exertion Physical exercise Coronary Disease Overweight law.invention Random Allocation Adenosine Triphosphate Randomized controlled trial law Physiology (medical) Internal medicine medicine Humans Platelet Obesity education education.field_of_study Clinical Trials as Topic business.industry Metabolic disorder Middle Aged medicine.disease Clinical trial Endocrinology Hypertension Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 74(5) |
| ISSN: | 0009-7322 |
| Popis: | It has been postulated that platelet function plays an important role in the initiation of atherosclerosis. Currently there are no definitive data on the longer-term effects of regular physical exercise on platelet function in humans. We assessed the influence of regular moderate-intensity physical exercise (brisk walking to slow jogging) on platelet aggregation in a population-based sample of middle-aged, overweight, mildly hypertensive men in eastern Finland. In this controlled study, we evaluated the net effect of exercise on platelet aggregation by studying changes in optical density and ATP release in platelet-rich plasma. A significant inhibition of secondary platelet aggregation from 27% to 36% was observed in the men taking regular exercise. These findings give new insight into the possible protective effects of exercise against the risk of ischemic heart disease. |
| Databáze: | OpenAIRE |
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