In vivo evaluation of three different 99mTc-labelled radiopharmaceuticals for sentinel lymph node identification
| Autor: | M. Edreira, E. O. Sajaroff, L. L. Colombo, S. G. de Castiglia, J. H. Perez |
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| Rok vydání: | 2001 |
| Předmět: |
Antimony
Pathology medicine.medical_specialty Sentinel lymph node chemistry.chemical_element Mice Inbred Strains Adenocarcinoma Technetium Sulphur colloid Scintigraphy Colloid Mice In vivo medicine Animals Humans Radiology Nuclear Medicine and imaging Tissue Distribution Radionuclide Imaging Serum Albumin Mice Inbred BALB C medicine.diagnostic_test business.industry Sentinel Lymph Node Biopsy digestive oral and skin physiology Mammary Neoplasms Experimental Reproducibility of Results Dextrans General Medicine Organotechnetium Compounds Human serum albumin Dextran 70 Technetium Compounds chemistry Lymphatic Metastasis Female Lymph Nodes Radiopharmaceuticals business medicine.drug |
| Zdroj: | Nuclear medicine communications. 22(5) |
| ISSN: | 0143-3636 |
| Popis: | This work was designed to compare sentinel lymph node (SLN) uptake of 99mTc-labelled human serum albumin colloid (99mTc-HSAC), 99mTc-labelled antimony sulphur colloid (99mTc-SC) and a 99mTc-labelled dextran 70 solution (99mTc-Dx) and their selectivity in the identification of this node in the right rear footpad (RRF) of normal mice and tumour bearing mice. Radiopharmaceutical uptake in the SLN (popliteal lymph node) and the lumbar lymph node (LLN), the second lymphatic node station from RRF, were measured at different time points post-intradermal or intratumoural injection into the RRF of NIH normal mice and of Balb/c mice harbouring the murine mammary tumour M2. 99mTc-HSAC uptake in the SLN was significantly higher than LLN uptake. The 99mTc-SC demonstrated high uptake in SLN, but accumulation in LLN was also high. 99mTc-Dx showed low uptakes in both SLN and LLN. The intradermal injection resulted in a more effective radiopharmaceutical accumulation in SLN than did the intratumoural inoculation. Data also show that increments in tumour volume reduced radiopharmaceutical uptake in the SLN. Our results show that 99mTc-HSAC exhibits the highest uptake in the SLN combined with the smallest amounts of radiopharmaceutical passing through to the LLN. Therefore, 99mTc-HSAC appears to be the best radiopharmaceutical for sentinel node detection. |
| Databáze: | OpenAIRE |
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