Association of Interleukin-23R Gene Polymorphisms with Behcet's Disease Susceptibility: A Meta-Analysis of Case-control Studies
| Autor: | Xiong-ming Pu, Hai-bo Gong, Xiao-jing Kang, Xiujuan Wu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Immunology Disease Behcet's disease Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Databases Genetic Odds Ratio Medicine Humans Genetic Predisposition to Disease Association (psychology) Gene Pathological Genetic Association Studies business.industry Behcet Syndrome Case-control study Interleukin General Medicine Receptors Interleukin medicine.disease stomatognathic diseases 030104 developmental biology 030220 oncology & carcinogenesis Meta-analysis Case-Control Studies business Publication Bias |
| Zdroj: | Immunological investigations. 49(6) |
| ISSN: | 1532-4311 |
| Popis: | The pathological mechanisms associated with the occurrence and development of Behcet's disease (BD) are not yet known. Two large genome-wide association surveys revealed an association between interleukin (IL)-23R single nucleotide polymorphism and BD. This study aimed to investigate the association between IL-23R gene polymorphisms and BD susceptibility.Comprehensive literature search was performed across four online databases - PubMed, Embase, Cochrane Library, and Web of science. The included studies had to be published before May 15, 2019. The Newcastle-Ottawa scale was used to assess the quality of every included study, and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using the allele model of inheritance to evaluate the potential associations between IL-23R gene polymorphisms and BD risk.In all, 12 case-control studies comprising 6,926 BD patients and 10,211 controls were identified and included in this meta-analysis, in which 5 loci of IL-23R gene polymorphisms were investigated. Of these 5 loci, 2 were found to be significantly associated with BD susceptibility: rs17375018 (G vs. A, OR = 1.50, 95% CI: 1.34-1.68,This meta-analysis indicated that rs17375018 (G/A) and rs924080 (T/C) were associated with BD susceptibility. However, association of the other IL-23R polymorphisms could not be estimated owing to the lack of studies.BD: Behcet's disease; SNP: single nucleotide polymorphism; HLA: human leukocyte antigen; IL: interleukin; OR: odds ratio; CI: confidence interval; HWE: Hardy-Weinberg equilibrium; UK: United Kingdom; NOS: Newcastle-Ottawa scale; GWAS: genome-wide association study; TNF-α: tumor necrosis factor-α. |
| Databáze: | OpenAIRE |
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