Prevention of Malaria during Pregnancy: Assessing the Effect of the Distribution of IPTp Through the National Policy in Benin
| Autor: | Gilles Cottrell, Célia Dechavanne, Agnès Le Port, Achille Massougbodji, Aziz Bouraima, Michel Cot, Benjamin Fayomi, Florence Migot-Nabias, José Guerra, André Garcia, Isabelle Choudat, Valérie Briand |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Sulfadoxine Placenta medicine.medical_treatment HIV Infections law.invention Antimalarials Young Adult Randomized controlled trial Pregnancy Risk Factors law Chloroquine Virology parasitic diseases medicine Benin Humans Obstetrics Mefloquine business.industry Health Policy Infant Newborn Articles Infant Low Birth Weight medicine.disease Malaria Surgery Clinical trial Drug Combinations Low birth weight Pyrimethamine Infectious Diseases Pregnancy Complications Parasitic Multivariate Analysis Female Parasitology medicine.symptom business Maternal Age medicine.drug |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 84:270-275 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.2011.10-0319 |
| Popis: | The efficiency of malaria prevention during pregnancy was compared between three studies in Benin for malaria infection of the placenta (MIP) and low birth weight (LBW). The first was carried out when chloroquine prophylaxis was still recommended, the second was an intermittent preventive treatment in pregnancy (IPTp) clinical trial comparing sulfadoxine pyrimetamine (SP) versus mefloquine, and the third was an observational study after SP-IPTp national implementation. We showed an association between the use of IPTp and the reduction of LBW (10% with national IPTp and 8.7% in IPTp trial versus 15.7% in pre-trial study). The effect on MIP was better in the trial (2.9% versus 11.2% and 16.7% for national IPTp and pre-trial studies, respectively). In spite of a good overall compliance with the national IPTp (with 84% of women taking at least one dose of SP), there are still failures in adherence to the directly observed therapy (DOT) scheme and needs for better training of health staff. |
| Databáze: | OpenAIRE |
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