Antimicrobial Effect of Albumin on Bacteria and Yeast Cells
| Autor: | O A Svitich, V G Arzumanyan, I M Ozhovan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Staphylococcus aureus Microbial Sensitivity Tests medicine.disease_cause General Biochemistry Genetics and Molecular Biology Microbiology 03 medical and health sciences 0302 clinical medicine Anti-Infective Agents Albumins Yeasts Candida albicans Escherichia coli medicine Animals Humans Bovine serum albumin Cryptococcus neoformans Bacteria Dose-Response Relationship Drug biology Chemistry Albumin General Medicine biology.organism_classification Antimicrobial Human serum albumin Yeast 030104 developmental biology biology.protein Cattle 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 167:763-766 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | We studied the effect of albumin (human serum, bovine serum, and ovalbumin) on Candida albicans, Cryptococcus neoformans, E. coli, and Staphylococcus aureus cells. Antimicrobial activity was evaluated by microscopy, inoculation, and spectrophotometry. All three albumins showed antimicrobial activity against all studied cultures and their effect was dose-dependent. At concentrations of serum albumins close to physiological (50 mg/ml), the cells of microorganisms were destroyed with the formation of debris vesicles, while at lower concentrations (10 mg/ml), only cell membrane integrity was impaired. According to spectrophotometry, activity of the human serum albumin in a physiological concentration against the studied microorganisms was close to the activity of native human serum. |
| Databáze: | OpenAIRE |
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